Anna B Skalska1, Agata Pietrzycka, Marek Stepniewski. 1. Department of Internal Medicine and Gerontology, Faculty of Medicine, Jagiellonian University Medical College, ul. Sniadeckich 10, 31-531 Krakow, Poland. anskal@su.krakow.pl
Abstract
UNLABELLED: Experimental studies confirmed that reactive oxygen species increase endothelin-1 (ET-1) synthesis, and modulate ET-1 signaling pathway resulting in vasoconstriction and vascular remodeling. The aim of this study was to evaluate the relationship between plasma ET-1 concentration and antioxidant status in patients with essential hypertension and type 2 diabetes mellitus. METHODS: 78 hypertensive patients, 53.8% diabetic, mean age 72.1+/-7.07 were examined. The plasma concentration of glucose, creatinine, uric acid, bilirubin, cholesterol, insulin, HbA1c and ET-1 were measured. Antioxidant status was assessed by Ferric Reducing Ability of Plasma (FRAP), vitamin C concentration and erythrocyte superoxide dismutase (SOD) activity. RESULTS: With diabetes ET-1 concentration was higher (1.35+/-0.51 vs 1.12+/-0.46 pg/mL, p=0.04). The negative correlations between ET-1 concentration and FRAP (r=-0.50, p<0.0001), vitamin C (r=-0.296, p=0.01) and SOD (r=-0.44, p=0.001) were found. Concentration of ET-1 correlated positively with SBP (r=0.33, p=0.005) but not with DBP. The relationship between DBP and ET-1 only in subjects with DBP>110 mm Hg and FRAP<0.40 mmol/L was found. In multiple regression analysis plasma ET-1 levels were associated independently with FRAP (beta=-0.583, p=0.003) and plasma vitamin C (beta=-0.407, p=0.04). CONCLUSIONS: In hypertensive and diabetic patients higher plasma endothelin-1 level was independently associated with lower plasma antioxidant status measured by FRAP and decreased vitamin C concentration, which may be a result of increased oxidative stress in these diseases.
UNLABELLED: Experimental studies confirmed that reactive oxygen species increase endothelin-1 (ET-1) synthesis, and modulate ET-1 signaling pathway resulting in vasoconstriction and vascular remodeling. The aim of this study was to evaluate the relationship between plasma ET-1 concentration and antioxidant status in patients with essential hypertension and type 2 diabetes mellitus. METHODS: 78 hypertensivepatients, 53.8% diabetic, mean age 72.1+/-7.07 were examined. The plasma concentration of glucose, creatinine, uric acid, bilirubin, cholesterol, insulin, HbA1c and ET-1 were measured. Antioxidant status was assessed by Ferric Reducing Ability of Plasma (FRAP), vitamin C concentration and erythrocyte superoxide dismutase (SOD) activity. RESULTS: With diabetesET-1 concentration was higher (1.35+/-0.51 vs 1.12+/-0.46 pg/mL, p=0.04). The negative correlations between ET-1 concentration and FRAP (r=-0.50, p<0.0001), vitamin C (r=-0.296, p=0.01) and SOD (r=-0.44, p=0.001) were found. Concentration of ET-1 correlated positively with SBP (r=0.33, p=0.005) but not with DBP. The relationship between DBP and ET-1 only in subjects with DBP>110 mm Hg and FRAP<0.40 mmol/L was found. In multiple regression analysis plasma ET-1 levels were associated independently with FRAP (beta=-0.583, p=0.003) and plasma vitamin C (beta=-0.407, p=0.04). CONCLUSIONS: In hypertensive and diabeticpatients higher plasma endothelin-1 level was independently associated with lower plasma antioxidant status measured by FRAP and decreased vitamin C concentration, which may be a result of increased oxidative stress in these diseases.
Authors: Ali Aydin; Zekai Halici; Erol Akpinar; A Murat Aksakal; Murat Saritemur; Muhammed Yayla; C Semih Kunak; Elif Cadirci; H Tarik Atmaca; S Sena Karcioglu Journal: J Bone Miner Metab Date: 2014-10-09 Impact factor: 2.626
Authors: Jan Szewieczek; Tomasz Francuz; Jan Dulawa; Katarzyna Legierska; Beata Hornik; Iwona Włodarczyk; Magdalena Janusz-Jenczeń; Agnieszka Batko-Szwaczka Journal: Age (Dordr) Date: 2015-08-21