Literature DB >> 19041990

Kuguacins F-S, cucurbitane triterpenoids from Momordica charantia.

Jian-Chao Chen1, Wu-Qing Liu, Lu Lu, Ming-Hua Qiu, Yong-Tang Zheng, Liu-Meng Yang, Xian-Min Zhang, Lin Zhou, Zhong-Rong Li.   

Abstract

Chemical investigation of the vines and leaves of Momordica charantia resulted in isolation of fourteen cucurbitane triterpenoids, kuguacins F-S (1-14), including two pentanorcucurbitacins (6 and 7), one octanorcucurbitacin (8), and two trinorcucurbitacins (11 and 12), along with six known analogues. Their structures were elucidated on the basis of extensive spectroscopic and single-crystal X-ray diffraction analyses. Compounds 1-14 exhibited weak anti-HIV-1 activities in vitro.

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Year:  2008        PMID: 19041990     DOI: 10.1016/j.phytochem.2008.10.011

Source DB:  PubMed          Journal:  Phytochemistry        ISSN: 0031-9422            Impact factor:   4.072


  12 in total

1.  Cucurbitane-Type Triterpenoids from the Vines of Momordica charantia and Their Anti-inflammatory Activities.

Authors:  Hung-Tse Huang; Li-Jie Zhang; Hui-Chi Huang; Syh-Yuan Hwang; Chia-Lun Wu; Yu-Chi Lin; Chia-Ching Liaw; Yung-Yi Cheng; Susan L Morris-Natschke; Chung-Yi Huang; Kuo-Hsiung Lee; Yao-Haur Kuo
Journal:  J Nat Prod       Date:  2020-05-01       Impact factor: 4.050

2.  Kuguacin J isolated from bitter melon leaves modulates paclitaxel sensitivity in drug-resistant human ovarian cancer cells.

Authors:  Pornsiri Pitchakarn; Sonthaya Umsumarng; Sariya Mapoung; Pisamai Ting; Piya Temviriyanukul; Wanisa Punfa; Wilart Pompimon; Pornngarm Limtrakul
Journal:  J Nat Med       Date:  2017-06-21       Impact factor: 2.343

3.  Kuguacin J isolated from Momordica charantia leaves inhibits P-glycoprotein (ABCB1)-mediated multidrug resistance.

Authors:  Pornsiri Pitchakarn; Shinobu Ohnuma; Komsak Pintha; Wilart Pompimon; Suresh V Ambudkar; Pornngarm Limtrakul
Journal:  J Nutr Biochem       Date:  2011-03-16       Impact factor: 6.048

Review 4.  Recent advances in natural anti-HIV triterpenoids and analogs.

Authors:  Hai-Feng Wu; Susan L Morris-Natschke; Xu-Dong Xu; Mei-Hua Yang; Yung-Yi Cheng; Shi-Shan Yu; Kuo-Hsiung Lee
Journal:  Med Res Rev       Date:  2020-07-14       Impact factor: 12.944

Review 5.  Bitter melon: a panacea for inflammation and cancer.

Authors:  Prasad R Dandawate; Dharmalingam Subramaniam; Subhash B Padhye; Shrikant Anant
Journal:  Chin J Nat Med       Date:  2016-02

6.  Inhibition of nuclear transcription factor-κB and activation of peroxisome proliferator-activated receptors in HepG2 cells by cucurbitane-type triterpene glycosides from Momordica charantia.

Authors:  Nguyen Xuan Nhiem; Pham Hai Yen; Nguyen Thi Thanh Ngan; Tran Hong Quang; Phan Van Kiem; Chau Van Minh; Bui Huu Tai; Nguyen Xuan Cuong; Seok Bean Song; Young Ho Kim
Journal:  J Med Food       Date:  2012-01-16       Impact factor: 2.786

7.  Teratogenic effect of the water extract of bitter gourd (Momordica charantia) on the Sprague Dawley rats.

Authors:  Edward O Uche-Nwachi; Carol McEwen
Journal:  Afr J Tradit Complement Altern Med       Date:  2009-10-15

Review 8.  Beneficial role of bitter melon supplementation in obesity and related complications in metabolic syndrome.

Authors:  Md Ashraful Alam; Riaz Uddin; Nusrat Subhan; Md Mahbubur Rahman; Preeti Jain; Hasan Mahmud Reza
Journal:  J Lipids       Date:  2015-01-12

9.  Cucurbitane-Type Triterpenoids from the Blood Glucose-Lowering Extracts of Coccinia indica and Momordica balsamina Fruits.

Authors:  Ujjwal Kaushik; Vidhu Aeri; R Mir Showkat; Mohammad Ali
Journal:  Pharmacogn Mag       Date:  2017-04-07       Impact factor: 1.085

10.  Model Analytical Development for Physical, Chemical, and Biological Characterization of Momordica charantia Vegetable Drug.

Authors:  Deysiane Oliveira Brandão; Geovani Pereira Guimarães; Ravely Lucena Santos; Fernando José de Lima Ramos Júnior; Karla Monik Alves da Silva; Fabio Santos de Souza; Rui Oliveira Macêdo
Journal:  J Anal Methods Chem       Date:  2016-08-07       Impact factor: 2.193

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