Literature DB >> 32357011

Cucurbitane-Type Triterpenoids from the Vines of Momordica charantia and Their Anti-inflammatory Activities.

Hung-Tse Huang1, Li-Jie Zhang1,2, Hui-Chi Huang3, Syh-Yuan Hwang4, Chia-Lun Wu5, Yu-Chi Lin1, Chia-Ching Liaw1,6, Yung-Yi Cheng7,8, Susan L Morris-Natschke7,8, Chung-Yi Huang5, Kuo-Hsiung Lee7,8, Yao-Haur Kuo1,9.   

Abstract

Seven new cucurbitane-type triterpenoids, kuguaovins A-G (1-7), and five known ones were isolated from the rattans of wild Momordica charantia. Their structures were established by spectroscopic data analyses, including 1D and 2D NMR, IR, and MS techniques. The absolute configurations of the cucurbitanes were determined from NOESY data and partially by X-ray crystallographic analysis. In pharmacological studies, compounds 1-7 and 9-12 exhibited weak anti-inflammatory effects (IC50 = 15-35 μM), based on an anti-NO production assay.

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Year:  2020        PMID： 32357011      PMCID： PMC8173961          DOI： 10.1021/acs.jnatprod.9b00592

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  23 in total

1.  Bitter melon (Momordica charantia) extract inhibits breast cancer cell proliferation by modulating cell cycle regulatory genes and promotes apoptosis.

Authors:  Ratna B Ray; Amit Raychoudhuri; Robert Steele; Pratibha Nerurkar
Journal:  Cancer Res       Date:  2010-02-23       Impact factor: 12.701

2.  Cucurbitane triterpenoids from Momordica charantia.

Authors:  Qing-Yan Li; Hu-Biao Chen; Zhen-Ming Liu; Bin Wang; Yu-Ying Zhao
Journal:  Magn Reson Chem       Date:  2007-06       Impact factor: 2.447

Review 3.  Bitter gourd (Momordica charantia) is a cornucopia of health: a review of its credited antidiabetic, anti-HIV, and antitumor properties.

Authors:  E F Fang; T B Ng
Journal:  Curr Mol Med       Date:  2011-07       Impact factor: 2.222

4.  Medicinal foodstuffs. XXI. Structures of new cucurbitane-type triterpene glycosides, goyaglycosides-a, -b, -c, -d, -e, -f, -g, and -h, and new oleanane-type triterpene saponins, goyasaponins I, II, and III, from the fresh fruit of Japanese Momordica charantia L.

Authors:  T Murakami; A Emoto; H Matsuda; M Yoshikawa
Journal:  Chem Pharm Bull (Tokyo)       Date:  2001-01       Impact factor: 1.645

5.  Extraction, quantification, and antioxidant activities of phenolics from pericarp and seeds of bitter melons (Momordica charantia) harvested at three maturity stages (immature, mature, and ripe).

Authors:  Ronny Horax; Navam Hettiarachchy; Pengyin Chen
Journal:  J Agric Food Chem       Date:  2010-04-14       Impact factor: 5.279

6.  Cucurbitane triterpenoids from the fruit of Momordica charantia L. and their anti-hepatic fibrosis and anti-hepatoma activities.

Authors:  Jiayin Yue; Yuanyuan Sun; Jing Xu; Jiaqing Cao; Gang Chen; Huixing Zhang; Xiaoshu Zhang; Yuqing Zhao
Journal:  Phytochemistry       Date:  2018-10-22       Impact factor: 4.072

7.  In vivo antitumor activity of the bitter melon (Momordica charantia).

Authors:  C Jilka; B Strifler; G W Fortner; E F Hays; D J Takemoto
Journal:  Cancer Res       Date:  1983-11       Impact factor: 12.701

8.  Potentiation of anti-HIV activity of anti-inflammatory drugs, dexamethasone and indomethacin, by MAP30, the antiviral agent from bitter melon.

Authors:  A S Bourinbaiar; S Lee-Huang
Journal:  Biochem Biophys Res Commun       Date:  1995-03-17       Impact factor: 3.575

9.  Fruit extracts of Momordica charantia potentiate glucose uptake and up-regulate Glut-4, PPAR gamma and PI3K.

Authors:  Ramadhar Kumar; S Balaji; T S Uma; P K Sehgal
Journal:  J Ethnopharmacol       Date:  2009-09-08       Impact factor: 4.360

Review 10.  Application of Herbal Medicines with Bitter Flavor and Cold Property on Treating Diabetes Mellitus.

Authors:  Hongdong Chen; Jing Guo; Bing Pang; Linhua Zhao; Xiaolin Tong
Journal:  Evid Based Complement Alternat Med       Date:  2015-10-18       Impact factor: 2.629
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  1 in total

1.  Four cucurbitane glycosides taimordisins A-D with novel furopyranone skeletons isolated from the fruits of Momordica charantia.

Authors:  Chia-Ching Liaw; I-Wen Lo; Yu-Chi Lin; Hung-Tse Huang; Li-Jie Zhang; Pin-Chun Hsiao; Tsung-Lin Li; Yao-Haur Kuo
Journal:  Food Chem X       Date:  2022-03-16
  1 in total

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