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Literature DB >> 19036478

A novel and efficient one step synthesis of 2-amino-5-cyano-6-hydroxy-4-aryl pyrimidines and their anti-bacterial activity.

M B Deshmukh¹, S M Salunkhe, D R Patil, P V Anbhule.

Abstract

The first simple and efficient approach towards one step synthesis of 2-amino-5-cyano-6-hydroxy-4-aryl pyrimidines has been developed by three component condensation of aromatic aldehydes, ethyl cyanoacetate and guanidine hydrochloride in alkaline ethanol. The synthesized compounds evaluated for their anti-bacterial activity against gram-positive and gram-negative bacteria. The some of the compounds showed excellent zone of inhibition against tested bacteria.

Entities: Chemical

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Year: 2008 PMID： 19036478 DOI： 10.1016/j.ejmech.2008.10.018

Source DB: PubMed Journal: Eur J Med Chem ISSN： 0223-5234 Impact factor: 6.514

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Cited

18 in total

1. One-pot synthesis, X-ray crystal structure, and identification of potential molecules against COVID-19 main protease through structure-guided modeling and simulation approach.

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2. Synthesis and antimicrobial evaluation of novel 4-amino-6-(1,3,4-oxadiazolo/1,3,4-thiadiazolo)-pyrimidine derivatives.

Authors: Poornima Shetty; B M Praveen; M Raghavendra; K Manjunath; Srinivas Cheruku
Journal: Mol Divers Date: 2015-10-26 Impact factor: 2.943

3. Synthesis of tetrahydropyrimidin-2-ones via FeCl3 catalyzed one-pot domino reaction of amines, methyl propiolate, aromatic aldehydes, and urea.

Authors: Li-Li Zhang; Jing Sun; Chao-Guo Yan
Journal: Mol Divers Date: 2013-10-25 Impact factor: 2.943

4. Spectroscopic analysis on the binding interaction of biologically active pyrimidine derivative with bovine serum albumin.

Authors: Vishwas D Suryawanshi; Laxman S Walekar; Anil H Gore; Prashant V Anbhule; Govind B Kolekar
Journal: J Pharm Anal Date: 2015-07-15

5. One pot synthesis, antimicrobial and antioxidant activities of fused uracils: pyrimidodiazepines, lumazines, triazolouracil and xanthines.

Authors: Samar A El-Kalyoubi; Eman A Fayed; Ahmed S Abdel-Razek
Journal: Chem Cent J Date: 2017-07-19 Impact factor: 4.215

6. Structural Insights of Three 2,4-Disubstituted Dihydropyrimidine-5-carbonitriles as Potential Dihydrofolate Reductase Inhibitors.

Authors: Lamya H Al-Wahaibi; Althaf Shaik; Mohammed A Elmorsy; Mohammed S M Abdelbaky; Santiago Garcia-Granda; Subbiah Thamotharan; Vijay Thiruvenkatam; Ali A El-Emam
Journal: Molecules Date: 2021-05-29 Impact factor: 4.411

A novel and efficient one step synthesis of 2-amino-5-cyano-6-hydroxy-4-aryl pyrimidines and their anti-bacterial activity.

1. One-pot synthesis, X-ray crystal structure, and identification of potential molecules against COVID-19 main protease through structure-guided modeling and simulation approach.

2. Synthesis and antimicrobial evaluation of novel 4-amino-6-(1,3,4-oxadiazolo/1,3,4-thiadiazolo)-pyrimidine derivatives.

3. Synthesis of tetrahydropyrimidin-2-ones via FeCl3 catalyzed one-pot domino reaction of amines, methyl propiolate, aromatic aldehydes, and urea.

4. Spectroscopic analysis on the binding interaction of biologically active pyrimidine derivative with bovine serum albumin.

5. One pot synthesis, antimicrobial and antioxidant activities of fused uracils: pyrimidodiazepines, lumazines, triazolouracil and xanthines.

6. Structural Insights of Three 2,4-Disubstituted Dihydropyrimidine-5-carbonitriles as Potential Dihydrofolate Reductase Inhibitors.

7. Synthesis and Antimicrobial Activity of some Tetrahydro Quinolone Diones and Pyrano[2,3-d]pyrimidine Derivatives.

8. (2Z)-3-(2,4-Di-chloro-phen-yl)-3-hy-droxy-N-phenyl-prop-2-ene-thio-amide.

9. Synthesis, antifungal activity, and QSAR studies of 1,6-dihydropyrimidine derivatives.

10. Crystal structure of 5,5'-[(4-fluoro-phen-yl)methyl-ene]bis-[6-amino-1,3-di-methyl-pyrimidine-2,4(1H,3H)-dione].