| Literature DB >> 19036015 |
N Douet-Guilbert1, J L Laï, A Basinko, N Gueganic, J Andrieux, B Pollet, I Plantier, C Delattre, O Crépin, S Corm, M J Le Bris, F Morel, M De Braekeleer.
Abstract
Isochromosome of the long arm of chromosome 20 with loss of interstitial material [ider(20q)] is a variant of deletion of chromosome 20q and a rare abnormality in myelodysplastic syndrome (MDS). We studied seven cases with an ider(20q) in MDS. Fluorescence in situ hybridization (FISH) studies showed all proximal breakpoints to be consistently located in 20q11.21 band whereas distal breakpoints were variable. Amplification of HCK, TNFRSF6B and DIDO1 genes included in retained regions associated with loss of tumour suppressor genes in deleted regions could explain cell tumour progression and possibly the less favourable prognosis of ider(20q) compared with del(20q).Entities:
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Year: 2008 PMID： 19036015 DOI： 10.1111/j.1365-2141.2008.07436.x
Source DB: PubMed Journal: Br J Haematol ISSN： 0007-1048 Impact factor: 6.998