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Literature DB >> 19035373

Extremely tight binding of a ruthenium complex to glycogen synthase kinase 3.

G Ekin Atilla-Gokcumen¹, Nicholas Pagano, Craig Streu, Jasna Maksimoska, Panagis Filippakopoulos, Stefan Knapp, Eric Meggers.

Abstract

Entities: CellLine Chemical Disease Gene Species

Mesh：

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Year: 2008 PMID： 19035373 PMCID： PMC4094351 DOI： 10.1002/cbic.200800489

Source DB: PubMed Journal: Chembiochem ISSN： 1439-4227 Impact factor: 3.164

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22 in total

1. An organometallic inhibitor for glycogen synthase kinase 3.

Authors: Howard Bregman; Douglas S Williams; G Ekin Atilla; Patrick J Carroll; Eric Meggers
Journal: J Am Chem Soc Date: 2004-10-27 Impact factor: 15.419

2. Switching on a signaling pathway with an organoruthenium complex.

Authors: Douglas S Williams; G Ekin Atilla; Howard Bregman; Arpine Arzoumanian; Peter S Klein; Eric Meggers
Journal: Angew Chem Int Ed Engl Date: 2005-03-18 Impact factor: 15.336

Review 3. Orthogonal multipolar interactions in structural chemistry and biology.

Authors: Ralph Paulini; Klaus Müller; François Diederich
Journal: Angew Chem Int Ed Engl Date: 2005-03-11 Impact factor: 15.336

4. Ruthenium half-sandwich complexes bound to protein kinase Pim-1.

Authors: Judit E Debreczeni; Alex N Bullock; G Ekin Atilla; Douglas S Williams; Howard Bregman; Stefan Knapp; Eric Meggers
Journal: Angew Chem Int Ed Engl Date: 2006-02-27 Impact factor: 15.336

5. Rapid access to unexplored chemical space by ligand scanning around a ruthenium center: discovery of potent and selective protein kinase inhibitors.

Authors: Howard Bregman; Patrick J Carroll; Eric Meggers
Journal: J Am Chem Soc Date: 2006-01-25 Impact factor: 15.419

6. An organometallic protein kinase inhibitor pharmacologically activates p53 and induces apoptosis in human melanoma cells.

Authors: Keiran S M Smalley; Rooha Contractor; Nikolas K Haass; Angela N Kulp; G Ekin Atilla-Gokcumen; Douglas S Williams; Howard Bregman; Keith T Flaherty; Maria S Soengas; Eric Meggers; Meenhard Herlyn
Journal: Cancer Res Date: 2007-01-01 Impact factor: 12.701

7. Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction.

Authors: Y Cheng; W H Prusoff
Journal: Biochem Pharmacol Date: 1973-12-01 Impact factor: 5.858

8. Organometallic compounds with biological activity: a very selective and highly potent cellular inhibitor for glycogen synthase kinase 3.

Authors: G Ekin Atilla-Gokcumen; Douglas S Williams; Howard Bregman; Nicholas Pagano; Eric Meggers
Journal: Chembiochem Date: 2006-09 Impact factor: 3.164

9. Ruthenium half-sandwich complexes as protein kinase inhibitors: an N-succinimidyl ester for rapid derivatizations of the cyclopentadienyl moiety.

Authors: Howard Bregman; Eric Meggers
Journal: Org Lett Date: 2006-11-23 Impact factor: 6.005

10. Tyrosine kinase inhibitors. 8. An unusually steep structure-activity relationship for analogues of 4-(3-bromoanilino)-6,7-dimethoxyquinazoline (PD 153035), a potent inhibitor of the epidermal growth factor receptor.

Authors: A J Bridges; H Zhou; D R Cody; G W Rewcastle; A McMichael; H D Showalter; D W Fry; A J Kraker; W A Denny
Journal: J Med Chem Date: 1996-01-05 Impact factor: 7.446

12 in total

Review 1. Application of metal coordination chemistry to explore and manipulate cell biology.

Authors: Kathryn L Haas; Katherine J Franz
Journal: Chem Rev Date: 2009-10 Impact factor: 60.622

2. Structurally sophisticated octahedral metal complexes as highly selective protein kinase inhibitors.

Authors: Li Feng; Yann Geisselbrecht; Sebastian Blanck; Alexander Wilbuer; G Ekin Atilla-Gokcumen; Panagis Filippakopoulos; Katja Kräling; Mehmet Ali Celik; Klaus Harms; Jasna Maksimoska; Ronen Marmorstein; Gernot Frenking; Stefan Knapp; Lars-Oliver Essen; Eric Meggers
Journal: J Am Chem Soc Date: 2011-03-29 Impact factor: 15.419

3. An organometallic inhibitor for the human repair enzyme 7,8-dihydro-8-oxoguanosine triphosphatase.

Authors: Manuel Streib; Katja Kräling; Kristin Richter; Xiulan Xie; Holger Steuber; Eric Meggers
Journal: Angew Chem Int Ed Engl Date: 2013-11-20 Impact factor: 15.336

4. Discovery of the First-in-Class GSK-3β/HDAC Dual Inhibitor as Disease-Modifying Agent To Combat Alzheimer's Disease.

Authors: Angela De Simone; Valeria La Pietra; Nibal Betari; Nicola Petragnani; Mariarosaria Conte; Simona Daniele; Deborah Pietrobono; Claudia Martini; Sabrina Petralla; Raffaella Casadei; Lara Davani; Flavia Frabetti; Pasquale Russomanno; Ettore Novellino; Serena Montanari; Vincenzo Tumiatti; Patrizia Ballerini; Federica Sarno; Angela Nebbioso; Lucia Altucci; Barbara Monti; Vincenza Andrisano; Andrea Milelli
Journal: ACS Med Chem Lett Date: 2019-02-04 Impact factor: 4.345

5. Structure of anticancer ruthenium half-sandwich complex bound to glycogen synthase kinase 3β.

Authors: G Ekin Atilla-Gokcumen; Luigi Di Costanzo; Eric Meggers
Journal: J Biol Inorg Chem Date: 2010-09-07 Impact factor: 3.358

6. From imide to lactam metallo-pyridocarbazoles: distinct scaffolds for the design of selective protein kinase inhibitors.

Authors: Nicholas Pagano; Eric Y Wong; Tom Breiding; Haidong Liu; Alexander Wilbuer; Howard Bregman; Qi Shen; Scott L Diamond; Eric Meggers
Journal: J Org Chem Date: 2009-12-04 Impact factor: 4.354

7. GSK3β inhibition blocks melanoma cell/host interactions by downregulating N-cadherin expression and decreasing FAK phosphorylation.

Authors: Jobin K John; Kim H T Paraiso; Vito W Rebecca; Liliana P Cantini; Ethan V Abel; Nicholas Pagano; Eric Meggers; Rahel Mathew; Clemens Krepler; Victoria Izumi; Bin Fang; John M Koomen; Jane L Messina; Meenhard Herlyn; Keiran S M Smalley
Journal: J Invest Dermatol Date: 2012-07-19 Impact factor: 8.551