Literature DB >> 15742314

Switching on a signaling pathway with an organoruthenium complex.

Douglas S Williams1, G Ekin Atilla, Howard Bregman, Arpine Arzoumanian, Peter S Klein, Eric Meggers.   

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Year:  2005        PMID： 15742314     DOI： 10.1002/anie.200462501

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


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  15 in total

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4.  Synthesis and biological assessment of a ruthenium(II) cyclopentadienyl complex in breast cancer cells and on the development of zebrafish embryos.

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5.  Glycogen synthase kinase-3 is essential for β-arrestin-2 complex formation and lithium-sensitive behaviors in mice.

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6.  From imide to lactam metallo-pyridocarbazoles: distinct scaffolds for the design of selective protein kinase inhibitors.

Authors:  Nicholas Pagano; Eric Y Wong; Tom Breiding; Haidong Liu; Alexander Wilbuer; Howard Bregman; Qi Shen; Scott L Diamond; Eric Meggers
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7.  The crystal structure of BRAF in complex with an organoruthenium inhibitor reveals a mechanism for inhibition of an active form of BRAF kinase.

Authors:  Peng Xie; Craig Streu; Jie Qin; Howard Bregman; Nicholas Pagano; Eric Meggers; Ronen Marmorstein
Journal:  Biochemistry       Date:  2009-06-16       Impact factor: 3.162

8.  Structure-based design of an organoruthenium phosphatidyl-inositol-3-kinase inhibitor reveals a switch governing lipid kinase potency and selectivity.

Authors:  Peng Xie; Douglas S Williams; G Ekin Atilla-Gokcumen; Leslie Milk; Min Xiao; Keiran S M Smalley; Meenhard Herlyn; Eric Meggers; Ronen Marmorstein
Journal:  ACS Chem Biol       Date:  2008-05-16       Impact factor: 5.100

9.  Crystal structure of the PIM2 kinase in complex with an organoruthenium inhibitor.

Authors:  Alex N Bullock; Santina Russo; Ann Amos; Nicholas Pagano; Howard Bregman; Judit E Debreczeni; Wen Hwa Lee; Frank von Delft; Eric Meggers; Stefan Knapp
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Review 10.  Marine pyrrolocarbazoles and analogues: synthesis and kinase inhibition.

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