BACKGROUND: Programmed cell death 4 (PDCD4) is a newly discovered tumor suppressor. The aim of this study was to investigate the expression and prognostic significance of PDCD4 in epithelial ovarian cancer. MATERIALS AND METHODS: PDCD4 expression in 20 normal human ovaries and 69 serous ovarian tumors was examined by RT-PCR and immunohistochemistry. The relationships between PDCD4 expression, clinicopathological data and patient survival were evaluated. RESULTS: PDCD4 expression was found to be lost or significantly lower in serous cystadenocarcinomas compared with that in normal ovaries and serous cystadenomas (p<0.05). The loss or reduction of PDCD4 expression in serous cystadenocarcinomas was significantly associated with higher pathological grade (p=0.0118) and poorer disease-specific survival of patients (p=0.0011). Multivariant Cox regression analysis revealed that PDCD4 expression was an independent prognostic factor for serous cystadenocarcinoma. CONCLUSION: Lost or reduced PDCD4 expression is associated with the progression of serous cystadenocarcinomas and may serve as an important prognostic marker.
BACKGROUND:Programmed cell death 4 (PDCD4) is a newly discovered tumor suppressor. The aim of this study was to investigate the expression and prognostic significance of PDCD4 in epithelial ovarian cancer. MATERIALS AND METHODS:PDCD4 expression in 20 normal humanovaries and 69 serous ovarian tumors was examined by RT-PCR and immunohistochemistry. The relationships between PDCD4 expression, clinicopathological data and patient survival were evaluated. RESULTS:PDCD4 expression was found to be lost or significantly lower in serous cystadenocarcinomas compared with that in normal ovaries and serous cystadenomas (p<0.05). The loss or reduction of PDCD4 expression in serous cystadenocarcinomas was significantly associated with higher pathological grade (p=0.0118) and poorer disease-specific survival of patients (p=0.0011). Multivariant Cox regression analysis revealed that PDCD4 expression was an independent prognostic factor for serous cystadenocarcinoma. CONCLUSION: Lost or reduced PDCD4 expression is associated with the progression of serous cystadenocarcinomas and may serve as an important prognostic marker.
Authors: Marta M Fay; James M Clegg; Kimberly A Uchida; Matthew A Powers; Katharine S Ullman Journal: J Biol Chem Date: 2014-04-24 Impact factor: 5.157
Authors: Tanja Grkovic; Johanna S Blees; Nancy H Colburn; Tobias Schmid; Cheryl L Thomas; Curtis J Henrich; James B McMahon; Kirk R Gustafson Journal: J Nat Prod Date: 2011-05-03 Impact factor: 4.050
Authors: Johanna S Blees; Tobias Schmid; Cheryl L Thomas; Alyson R Baker; Lauren Benson; Jason R Evans; Ekaterina I Goncharova; Nancy H Colburn; James B McMahon; Curtis J Henrich Journal: J Biomol Screen Date: 2009-11-09
Authors: N A Wei; Stephanie S Liu; Thomas H Y Leung; Kar F Tam; Xiao Y Liao; Annie N Y Cheung; Karen K L Chan; Hextan Y S Ngan Journal: Mol Cancer Date: 2009-09-03 Impact factor: 27.401