BACKGROUND: The purpose of this study was to test the Union Internationale Contre le Cancer (UICC)/TNM category-based head and neck cancer stage grouping systems proposed in the literature for their ability to create clinically relevant prognostic groups of like-patients with cancer of the hypopharynx. METHODS: Population-based retrospective survival study of 595 patients with squamous cell carcinoma of the hypopharynx across Ontario, Canada, from January 1990 to January 2000. The grouping systems of UICC/TNM, T and N Integer Score (TANIS), Hart, Berg, Snyderman, Kiricuta, and Hall were tested and compared for prognostic ability using hazard consistency, hazard discrimination, percent variance explained, outcome prediction, and balance. RESULTS: All 8 systems predicted disease-specific survival. The system proposed by Snyderman performed the best, and UICC/TNM sixth edition did not perform as well as most. CONCLUSION: The UICC/TNM stage group classification, although successful in creating statistically distinct groups, did not perform as well as other stage grouping systems, continuing a theme that has been reported previously. (c) 2008 Wiley Periodicals, Inc. Head Neck, 2009.
BACKGROUND: The purpose of this study was to test the Union Internationale Contre le Cancer (UICC)/TNM category-based head and neck cancer stage grouping systems proposed in the literature for their ability to create clinically relevant prognostic groups of like-patients with cancer of the hypopharynx. METHODS: Population-based retrospective survival study of 595 patients with squamous cell carcinoma of the hypopharynx across Ontario, Canada, from January 1990 to January 2000. The grouping systems of UICC/TNM, T and N Integer Score (TANIS), Hart, Berg, Snyderman, Kiricuta, and Hall were tested and compared for prognostic ability using hazard consistency, hazard discrimination, percent variance explained, outcome prediction, and balance. RESULTS: All 8 systems predicted disease-specific survival. The system proposed by Snyderman performed the best, and UICC/TNM sixth edition did not perform as well as most. CONCLUSION: The UICC/TNM stage group classification, although successful in creating statistically distinct groups, did not perform as well as other stage grouping systems, continuing a theme that has been reported previously. (c) 2008 Wiley Periodicals, Inc. Head Neck, 2009.
Authors: M Amit; T C Yen; C T Liao; P Chaturvedi; J P Agarwal; L P Kowalski; Hugo F Kohler; A Ebrahimi; J R Clark; C R Cernea; S J Brandao; M Kreppel; J Zöller; M D Fliss; G Bachar; T Shpitzer; V A Bolzoni; P R Patel; S Jonnalagadda; K T Robbins; N G Iyer; T Skanthakumar; J P Shah; S G Patel; Z Gil Journal: Ann Surg Oncol Date: 2015-08-28 Impact factor: 5.344
Authors: A Kolk; N Jubitz; K Mengele; K Mantwill; O Bissinger; M Schmitt; M Kremer; P S Holm Journal: Br J Cancer Date: 2011-11-17 Impact factor: 7.640