Literature DB >> 19030971

Insulin receptor substrates (IRSs) and breast tumorigenesis.

Bonita Tak-Yee Chan1, Adrian V Lee.   

Abstract

Insulin receptor substrate (IRS)-1 and IRS-2 are adaptor proteins in the insulin-like growth factor I (IGF-I)/IGF-I receptor (IGF-IR) pathway that mediate cell proliferation, migration, and survival. In addition to their role as scaffolding proteins in the cytoplasm, they are able to translocate into the nucleus and regulate gene transcription. IRS levels are developmentally and hormonally regulated in the normal mammary gland and both are essential for normal mammary gland bud formation and lactation. Both IRS-1 and IRS-2 are transforming oncogenes, and induce transformation and metastasis in vitro and in vivo. In breast cancer IRSs have unique functions, with IRS-1 being mainly involved in cell proliferation and survival, whereas IRS-2 has clear roles in cell migration and metastasis. In this review we will discuss the roles of IRSs in mammary gland development and breast cancer.

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Year:  2008        PMID： 19030971      PMCID： PMC2819329          DOI： 10.1007/s10911-008-9101-9

Source DB:  PubMed          Journal:  J Mammary Gland Biol Neoplasia        ISSN： 1083-3021            Impact factor:   2.673


  82 in total

1.  Genetic variation in IGF1, IGFBP3, IRS1, IRS2 and risk of breast cancer in women living in Southwestern United States.

Authors:  M L Slattery; C Sweeney; R Wolff; J Herrick; K Baumgartner; A Giuliano; T Byers
Journal:  Breast Cancer Res Treat       Date:  2006-10-19       Impact factor: 4.872

Review 2.  Critical nodes in signalling pathways: insights into insulin action.

Authors:  Cullen M Taniguchi; Brice Emanuelli; C Ronald Kahn
Journal:  Nat Rev Mol Cell Biol       Date:  2006-02       Impact factor: 94.444

3.  Overexpression of human insulin receptor substrate 1 induces cellular transformation with activation of mitogen-activated protein kinases.

Authors:  T Ito; Y Sasaki; J R Wands
Journal:  Mol Cell Biol       Date:  1996-03       Impact factor: 4.272

4.  Involvement of insulin receptor substrate 2 in mammary tumor metastasis.

Authors:  Julie A Nagle; Zhefu Ma; Maura A Byrne; Morris F White; Leslie M Shaw
Journal:  Mol Cell Biol       Date:  2004-11       Impact factor: 4.272

5.  Interaction of insulin receptor substrate-2 (IRS-2) with the insulin and insulin-like growth factor I receptors. Evidence for two distinct phosphotyrosine-dependent interaction domains within IRS-2.

Authors:  W He; A Craparo; Y Zhu; T J O'Neill; L M Wang; J H Pierce; T A Gustafson
Journal:  J Biol Chem       Date:  1996-05-17       Impact factor: 5.157

6.  Growth hormone stimulates the tyrosine phosphorylation of the insulin receptor substrate-1 and its association with phosphatidylinositol 3-kinase in primary adipocytes.

Authors:  M Ridderstråle; E Degerman; H Tornqvist
Journal:  J Biol Chem       Date:  1995-02-24       Impact factor: 5.157

7.  Insulin receptor substrate-2 binds to the insulin receptor through its phosphotyrosine-binding domain and through a newly identified domain comprising amino acids 591-786.

Authors:  D Sawka-Verhelle; S Tartare-Deckert; M F White; E Van Obberghen
Journal:  J Biol Chem       Date:  1996-03-15       Impact factor: 5.157

8.  Insulin receptor substrate 1 modulates the transcriptional activity and the stability of androgen receptor in breast cancer cells.

Authors:  Marilena Lanzino; Cecilia Garofalo; Catia Morelli; Maria Le Pera; Ivan Casaburi; Michael J McPhaul; Eva Surmacz; Sebastiano Andò; Diego Sisci
Journal:  Breast Cancer Res Treat       Date:  2008-06-04       Impact factor: 4.872

Review 9.  The new elements of insulin signaling. Insulin receptor substrate-1 and proteins with SH2 domains.

Authors:  M G Myers; M F White
Journal:  Diabetes       Date:  1993-05       Impact factor: 9.461

10.  Enhancement of insulin-like growth factor signaling in human breast cancer: estrogen regulation of insulin receptor substrate-1 expression in vitro and in vivo.

Authors:  A V Lee; J G Jackson; J L Gooch; S G Hilsenbeck; E Coronado-Heinsohn; C K Osborne; D Yee
Journal:  Mol Endocrinol       Date:  1999-05
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  29 in total

1.  Insulin-like growth factors I and II receptors in the breast cancer survival disparity among African-American women.

Authors:  S Kalla Singh; Q W Tan; C Brito; M De León; D De León
Journal:  Growth Horm IGF Res       Date:  2010-03-27       Impact factor: 2.372

2.  Molecular analysis of non-small cell lung cancer identifies subsets with different sensitivity to insulin-like growth factor I receptor inhibition.

Authors:  Antonio Gualberto; Marisa Dolled-Filhart; Mark Gustavson; Jason Christiansen; Yu-Fen Wang; Mary L Hixon; Jennifer Reynolds; Sandra McDonald; Agnes Ang; David L Rimm; Corey J Langer; Johnetta Blakely; Linda Garland; Luis G Paz-Ares; Daniel D Karp; Adrian V Lee
Journal:  Clin Cancer Res       Date:  2010-07-29       Impact factor: 12.531

Review 3.  [Obesity and cancer].

Authors:  H Ungefroren; F Gieseler; H Lehnert
Journal:  Internist (Berl)       Date:  2015-02       Impact factor: 0.743

4.  Therapeutic destruction of insulin receptor substrates for cancer treatment.

Authors:  Hadas Reuveni; Efrat Flashner-Abramson; Lilach Steiner; Kirill Makedonski; Renduo Song; Alexei Shir; Meenhard Herlyn; Menashe Bar-Eli; Alexander Levitzki
Journal:  Cancer Res       Date:  2013-05-07       Impact factor: 12.701

5.  Investigation of insulin resistance gene polymorphisms in patients with differentiated thyroid cancer.

Authors:  Mustafa Akker; Sibel Güldiken; Tammam Sipahi; Orkide Palabıyık; Ayhan Tosunoğlu; Özlem Çelik; Nermin Tunçbilek; Atakan Sezer; Necdet Süt
Journal:  Mol Biol Rep       Date:  2014-02-07       Impact factor: 2.316

6.  Insulin receptor substrate 1/2 (IRS1/2) regulates Wnt/β-catenin signaling through blocking autophagic degradation of dishevelled2.

Authors:  Yongtao Geng; Yanfang Ju; Fangli Ren; Ying Qiu; Yasuhiko Tomita; Miki Tomoeda; Mioka Kishida; Yinyin Wang; Lian Jin; Fuqin Su; Chunhong Wei; Baoqing Jia; Yi Li; Zhijie Chang
Journal:  J Biol Chem       Date:  2014-03-10       Impact factor: 5.157

7.  MHC-restricted phosphopeptides from insulin receptor substrate-2 and CDC25b offer broad-based immunotherapeutic agents for cancer.

Authors:  Angela L Zarling; Rebecca C Obeng; A Nicole Desch; Joel Pinczewski; Kara L Cummings; Donna H Deacon; Mark Conaway; Craig L Slingluff; Victor H Engelhard
Journal:  Cancer Res       Date:  2014-10-08       Impact factor: 12.701

8.  Insulin promotes proliferative vitality and invasive capability of pancreatic cancer cells via hypoxia-inducible factor 1alpha pathway.

Authors:  Li Wang; Wei Zhou; Shanmiao Gou; Tongling Wang; Tao Liu; Chunyou Wang
Journal:  J Huazhong Univ Sci Technolog Med Sci       Date:  2010-06-17

9.  O-linked N-acetylglucosamine modification of insulin receptor substrate-1 occurs in close proximity to multiple SH2 domain binding motifs.

Authors:  Amanda L Klein; Mary N Berkaw; Maria G Buse; Lauren E Ball
Journal:  Mol Cell Proteomics       Date:  2009-08-11       Impact factor: 5.911

10.  HER2/HER3 regulates extracellular acidification and cell migration through MTK1 (MEKK4).

Authors:  James J Sollome; Elangovan Thavathiru; Todd D Camenisch; Richard R Vaillancourt
Journal:  Cell Signal       Date:  2013-09-12       Impact factor: 4.315
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