Literature DB >> 19030970

Regulation of breast cancer metastasis by IGF signaling.

Deepali Sachdev1.   

Abstract

The insulin-like growth factors (IGFs) signaling via the type I insulin-like growth factor receptor (IGF-1R) regulate multiple aspects of malignancy. The importance of IGF-1R in regulating the malignant phenotype is currently being validated in numerous clinical trials for cancer including breast cancer. This review discusses the regulation of breast cancer metastasis by IGF-1R. IGF-1R stimulates invasion and survival in anchorage independent conditions. The regulation of metastasis independently of tumor growth by IGF-1R is also discussed. Finally, the impact of this on clinical trial design and outcomes, and the need for biomarkers, other than reduction in tumor size, are discussed in light of the fact that inhibition of metastasis is not measured in conventional clinical trial design.

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Year:  2008        PMID： 19030970     DOI： 10.1007/s10911-008-9105-5

Source DB:  PubMed          Journal:  J Mammary Gland Biol Neoplasia        ISSN： 1083-3021            Impact factor:   2.673


  100 in total

Review 1.  The IGF-1 receptor in cancer biology.

Authors:  Renato Baserga; Francesca Peruzzi; Krysztof Reiss
Journal:  Int J Cancer       Date:  2003-12-20       Impact factor: 7.396

2.  Hypoglycemic effect of insulin-like growth factor-1 in mice lacking insulin receptors.

Authors:  G Di Cola; M H Cool; D Accili
Journal:  J Clin Invest       Date:  1997-05-15       Impact factor: 14.808

3.  Blockade of insulin-like growth factor I receptor function inhibits growth and angiogenesis of colon cancer.

Authors:  Niels Reinmuth; Wenbiao Liu; Fan Fan; Young D Jung; Syed A Ahmad; Oliver Stoeltzing; Corazon D Bucana; Robert Radinsky; Lee M Ellis
Journal:  Clin Cancer Res       Date:  2002-10       Impact factor: 12.531

4.  Involvement of insulin receptor substrate 2 in mammary tumor metastasis.

Authors:  Julie A Nagle; Zhefu Ma; Maura A Byrne; Morris F White; Leslie M Shaw
Journal:  Mol Cell Biol       Date:  2004-11       Impact factor: 4.272

5.  Regulation of hypoxia-inducible factor-1alpha, vascular endothelial growth factor, and angiogenesis by an insulin-like growth factor-I receptor autocrine loop in human pancreatic cancer.

Authors:  Oliver Stoeltzing; Wenbiao Liu; Niels Reinmuth; Fan Fan; Alexander A Parikh; Corazon D Bucana; Douglas B Evans; Gregg L Semenza; Lee M Ellis
Journal:  Am J Pathol       Date:  2003-09       Impact factor: 4.307

6.  Low activation of Insulin-like Growth Factor 1-Receptor (IGF1R) is associated with local recurrence in early breast carcinoma.

Authors:  Gloria Peiró; Susana Benlloch; Laura Sánchez-Tejada; Encarna Adrover; Enrique Lerma; Francisca M Peiró; José Sánchez-Payá; F Ignacio Aranda
Journal:  Breast Cancer Res Treat       Date:  2008-08-06       Impact factor: 4.872

7.  Motility response to insulin-like growth factor-I (IGF-I) in MCF-7 cells is associated with IRS-2 activation and integrin expression.

Authors:  Xihong Zhang; Sailaja Kamaraju; Fumihiko Hakuno; Tomohiro Kabuta; Shin-Ichiro Takahashi; Deepali Sachdev; Douglas Yee
Journal:  Breast Cancer Res Treat       Date:  2004-01       Impact factor: 4.872

8.  Phase I dose escalation study of the anti insulin-like growth factor-I receptor monoclonal antibody CP-751,871 in patients with refractory solid tumors.

Authors:  Paul Haluska; Heather M Shaw; Gretchen N Batzel; Donghua Yin; Julian R Molina; L Rhoda Molife; Timothy A Yap; M Luisa Roberts; Amarnath Sharma; Antonio Gualberto; Alex A Adjei; Johann S de Bono
Journal:  Clin Cancer Res       Date:  2007-10-01       Impact factor: 12.531

9.  Loss of the metastatic phenotype in murine carcinoma cells expressing an antisense RNA to the insulin-like growth factor receptor.

Authors:  L Long; R Rubin; R Baserga; P Brodt
Journal:  Cancer Res       Date:  1995-03-01       Impact factor: 12.701

10.  Potential applications for circulating tumor cells expressing the insulin-like growth factor-I receptor.

Authors:  Johann S de Bono; Gerhardt Attard; Alex Adjei; Michael N Pollak; Peter C Fong; Paul Haluska; Luisa Roberts; Carrie Melvin; Madeline Repollet; David Chianese; Mark Connely; Leon W M M Terstappen; Antonio Gualberto
Journal:  Clin Cancer Res       Date:  2007-06-15       Impact factor: 12.531
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  17 in total

Review 1.  Minireview: Were the IGF Signaling Inhibitors All Bad?

Authors:  Heather Beckwith; Douglas Yee
Journal:  Mol Endocrinol       Date:  2015-09-14

2.  Flaxseed and its components differentially affect estrogen targets in pre-neoplastic hen ovaries.

Authors:  Anushka Dikshit; Chunqi Gao; Carrie Small; Karen Hales; Dale Buchanan Hales
Journal:  J Steroid Biochem Mol Biol       Date:  2016-02-27       Impact factor: 4.292

Review 3.  Targeting insulin and insulin-like growth factor signaling in breast cancer.

Authors:  Yuzhe Yang; Douglas Yee
Journal:  J Mammary Gland Biol Neoplasia       Date:  2012-10-10       Impact factor: 2.673

4.  Type 1 Insulin-Like Growth Factor Receptor/Insulin Receptor Substrate 1 Signaling Confers Pathogenic Activity on Breast Tumor Cells Lacking REST.

Authors:  Kassondra Meyer; Brittany Albaugh; Barry Schoenike; Avtar Roopra
Journal:  Mol Cell Biol       Date:  2015-06-22       Impact factor: 4.272

Review 5.  Evolution of breast cancer therapeutics: Breast tumour kinase's role in breast cancer and hope for breast tumour kinase targeted therapy.

Authors:  Haroon A Hussain; Amanda J Harvey
Journal:  World J Clin Oncol       Date:  2014-08-10

Review 6.  Hyperinsulinaemia in cancer.

Authors:  Emily J Gallagher; Derek LeRoith
Journal:  Nat Rev Cancer       Date:  2020-09-09       Impact factor: 60.716

7.  Enhancement of doxorubicin cytotoxicity of human cancer cells by tyrosine kinase inhibition of insulin receptor and type I IGF receptor.

Authors:  Xianke Zeng; Hua Zhang; Annabell Oh; Yan Zhang; Douglas Yee
Journal:  Breast Cancer Res Treat       Date:  2011-08-18       Impact factor: 4.872

8.  Prolactin enhances insulin-like growth factor I receptor phosphorylation by decreasing its association with the tyrosine phosphatase SHP-2 in MCF-7 breast cancer cells.

Authors:  Kristopher C Carver; Timothy M Piazza; Linda A Schuler
Journal:  J Biol Chem       Date:  2010-01-15       Impact factor: 5.157

9.  IGF-I induced genes in stromal fibroblasts predict the clinical outcome of breast and lung cancer patients.

Authors:  Michal Rajski; Rosanna Zanetti-Dällenbach; Brigitte Vogel; Richard Herrmann; Christoph Rochlitz; Martin Buess
Journal:  BMC Med       Date:  2010-01-05       Impact factor: 8.775

10.  Targeting insulin and insulin-like growth factor pathways in epithelial ovarian cancer.

Authors:  Marie-Claude Beauchamp; Amber Yasmeen; Ariane Knafo; Walter H Gotlieb
Journal:  J Oncol       Date:  2010-01-05       Impact factor: 4.375
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