AIM: To investigate the effect of a new infant formula supplemented with a low level (0.24 g/100 mL) of galacto-oligosaccharide (GOS) on intestinal micro-flora (Bifidobacteria, Lactobacilli and E. coli) and fermentation characteristics in term infants, compared with human milk and a standard infant formula without GOS. METHODS:Term infants (n = 371) were approached in this study in three hospitals of China. All infants started breast-feeding. Those who changed to formula-feeding within 4 wk after birth were randomly assigned to one of the two formula groups. Growth and stool characteristics, and side effects that occurred in recruited infants were recorded in a 3-mo follow-up period. Fecal samples were collected from a subpopulation of recruited infants for analysis of intestinal bacteria (culture technique), acetic acid (gas chromatography) and pH (indicator strip). RESULTS: After 3 mo, the intestinal Bifidobacteria, Lactobacilli, acetic acid and stool frequency were significantly increased, and fecal pH was decreased in infants fed with the GOS-formula or human milk, compared with those fed with the formula without GOS. No significant differences were observed between the GOS formula and human milk groups. Supplementation with GOS did not influence the incidence of crying, regurgitation and vomiting. CONCLUSION: A low level of GOS (0.24 g/100 mL) in infant formula can improve stool frequency, decrease fecal pH, and stimulate intestinal Bifidobacteria and Lactobacilli as in those fed with human milk.
RCT Entities:
AIM: To investigate the effect of a new infant formula supplemented with a low level (0.24 g/100 mL) of galacto-oligosaccharide (GOS) on intestinal micro-flora (Bifidobacteria, Lactobacilli and E. coli) and fermentation characteristics in term infants, compared with human milk and a standard infant formula without GOS. METHODS: Term infants (n = 371) were approached in this study in three hospitals of China. All infants started breast-feeding. Those who changed to formula-feeding within 4 wk after birth were randomly assigned to one of the two formula groups. Growth and stool characteristics, and side effects that occurred in recruited infants were recorded in a 3-mo follow-up period. Fecal samples were collected from a subpopulation of recruited infants for analysis of intestinal bacteria (culture technique), acetic acid (gas chromatography) and pH (indicator strip). RESULTS: After 3 mo, the intestinal Bifidobacteria, Lactobacilli, acetic acid and stool frequency were significantly increased, and fecal pH was decreased in infants fed with the GOS-formula or human milk, compared with those fed with the formula without GOS. No significant differences were observed between the GOS formula and human milk groups. Supplementation with GOS did not influence the incidence of crying, regurgitation and vomiting. CONCLUSION: A low level of GOS (0.24 g/100 mL) in infant formula can improve stool frequency, decrease fecal pH, and stimulate intestinal Bifidobacteria and Lactobacilli as in those fed with human milk.
Authors: H J Harmsen; A C Wildeboer-Veloo; G C Raangs; A A Wagendorp; N Klijn; J G Bindels; G W Welling Journal: J Pediatr Gastroenterol Nutr Date: 2000-01 Impact factor: 2.839
Authors: G Boehm; M Lidestri; P Casetta; J Jelinek; F Negretti; B Stahl; A Marini Journal: Arch Dis Child Fetal Neonatal Ed Date: 2002-05 Impact factor: 5.747
Authors: Janina A Krumbeck; María X Maldonado-Gomez; Inés Martínez; Steven A Frese; Thomas E Burkey; Karuna Rasineni; Amanda E Ramer-Tait; Edward N Harris; Robert W Hutkins; Jens Walter Journal: Appl Environ Microbiol Date: 2015-01-23 Impact factor: 4.792
Authors: Christian Milani; Sabrina Duranti; Francesca Bottacini; Eoghan Casey; Francesca Turroni; Jennifer Mahony; Clara Belzer; Susana Delgado Palacio; Silvia Arboleya Montes; Leonardo Mancabelli; Gabriele Andrea Lugli; Juan Miguel Rodriguez; Lars Bode; Willem de Vos; Miguel Gueimonde; Abelardo Margolles; Douwe van Sinderen; Marco Ventura Journal: Microbiol Mol Biol Rev Date: 2017-11-08 Impact factor: 11.056
Authors: A Monteagudo-Mera; J C Arthur; C Jobin; T Keku; J M Bruno-Barcena; M A Azcarate-Peril Journal: Benef Microbes Date: 2016-02-03 Impact factor: 4.205
Authors: Melinda A Engevik; Heather A Danhof; Anne Hall; Kristen A Engevik; Thomas D Horvath; Sigmund J Haidacher; Kathleen M Hoch; Bradley T Endres; Meghna Bajaj; Kevin W Garey; Robert A Britton; Jennifer K Spinler; Anthony M Haag; James Versalovic Journal: BMC Microbiol Date: 2021-05-24 Impact factor: 3.605