Literature DB >> 19028102

Bioactivities of simplified adociaquinone B and naphthoquinone derivatives against Cdc25B, MKP-1, and MKP-3 phosphatases.

Shugeng Cao1, Brian T Murphy, Caleb Foster, John S Lazo, David G I Kingston.   

Abstract

Some simplified adociaquinone B analogs and a series of 1,4-naphthoquinone derivatives were synthesized and tested against the three enzymes Cdc25B, MKP-1, and MKP-3. Cdc25B and MKP-1 in particular are enzymes overexpressed in human cancer cells, and they represent potential molecular targets for novel cancer chemotherapeutic treatments. A number of analogs exhibited significant inhibitory activity against these enzymes, and the bioassay data in addition to structure-activity relationships of these compounds will be discussed.

Entities:  

Mesh：

Substances：

Year:  2008        PMID： 19028102      PMCID： PMC2860877          DOI： 10.1016/j.bmc.2008.10.090

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  40 in total

Review 1.  Dual-specificity phosphatases as targets for antineoplastic agents.

Authors:  Michael A Lyon; Alexander P Ducruet; Peter Wipf; John S Lazo
Journal:  Nat Rev Drug Discov       Date:  2002-12       Impact factor: 84.694

2.  Catalytic mechanism of Cdc25.

Authors:  Johannes Rudolph
Journal:  Biochemistry       Date:  2002-12-10       Impact factor: 3.162

3.  Detection of peptide-lipid interactions in mixed monolayers, using isotherms, atomic force microscopy, and fourier transform infrared analyses.

Authors:  V Vié; N Van Mau; L Chaloin; E Lesniewska; C Le Grimellec; F Heitz
Journal:  Biophys J       Date:  2000-02       Impact factor: 4.033

4.  Role of the Cdc25A phosphatase in human breast cancer.

Authors:  M G Cangi; B Cukor; P Soung; S Signoretti; G Moreira; M Ranashinge; B Cady; M Pagano; M Loda
Journal:  J Clin Invest       Date:  2000-09       Impact factor: 14.808

5.  Identification of a potent and selective pharmacophore for Cdc25 dual specificity phosphatase inhibitors.

Authors:  John S Lazo; Kaoru Nemoto; Katharine E Pestell; Kathleen Cooley; Eileen C Southwick; Douglas A Mitchell; William Furey; Rick Gussio; Daniel W Zaharevitz; Beomjun Joo; Peter Wipf
Journal:  Mol Pharmacol       Date:  2002-04       Impact factor: 4.436

6.  Regulation of G(2)/M events by Cdc25A through phosphorylation-dependent modulation of its stability.

Authors:  Niels Mailand; Alexandre V Podtelejnikov; Anja Groth; Matthias Mann; Jiri Bartek; Jiri Lukas
Journal:  EMBO J       Date:  2002-11-01       Impact factor: 11.598

7.  Expression of mitogen-activated protein kinase phosphatase-1 (MKP-1) in primary human ovarian carcinoma.

Authors:  Carsten Denkert; Wolfgang D Schmitt; Stefan Berger; Angela Reles; Sören Pest; Antje Siegert; Werner Lichtenegger; Manfred Dietel; Steffen Hauptmann
Journal:  Int J Cancer       Date:  2002-12-10       Impact factor: 7.396

8.  Cdc25 inhibition and cell cycle arrest by a synthetic thioalkyl vitamin K analogue.

Authors:  K Tamura; E C Southwick; J Kerns; K Rosi; B I Carr; C Wilcox; J S Lazo
Journal:  Cancer Res       Date:  2000-03-01       Impact factor: 12.701

9.  The carcinogen (7R,8S)-dihydroxy-(9S,10R)-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene induces Cdc25B expression in human bronchial and lung cancer cells.

Authors:  Tetsuya Oguri; Shivendra V Singh; Kaoru Nemoto; John S Lazo
Journal:  Cancer Res       Date:  2003-02-15       Impact factor: 12.701

10.  Novel naphthoquinone and quinolinedione inhibitors of CDC25 phosphatase activity with antiproliferative properties.

Authors:  Emmanuelle Braud; Mary-Lorène Goddard; Stéphanie Kolb; Marie-Priscille Brun; Odile Mondésert; Muriel Quaranta; Nohad Gresh; Bernard Ducommun; Christiane Garbay
Journal:  Bioorg Med Chem       Date:  2008-08-07       Impact factor: 3.641
View more
  6 in total

1.  Identification of novel inhibitors of mitogen-activated protein kinase phosphatase-1 with structure-based virtual screening.

Authors:  Hwangseo Park; Jeong-Yi Jeon; Song Yi Kim; Dae Gwin Jeong; Seong Eon Ryu
Journal:  J Comput Aided Mol Des       Date:  2011-05-13       Impact factor: 3.686

2.  Synthesis, anticancer activity, and molecular modeling of 1,4-naphthoquinones that inhibit MKK7 and Cdc25.

Authors:  Igor A Schepetkin; Alexander S Karpenko; Andrei I Khlebnikov; Marina O Shibinska; Igor A Levandovskiy; Liliya N Kirpotina; Nadezhda V Danilenko; Mark T Quinn
Journal:  Eur J Med Chem       Date:  2019-09-18       Impact factor: 6.514

3.  Structures and mechanisms of antitumor agents: xestoquinones uncouple cellular respiration and disrupt HIF signaling in human breast tumor cells.

Authors:  Lin Du; Fakhri Mahdi; Sandipan Datta; Mika B Jekabsons; Yu-Dong Zhou; Dale G Nagle
Journal:  J Nat Prod       Date:  2012-08-31       Impact factor: 4.050

Review 4.  A Comprehensive Overview of the Developments of Cdc25 Phosphatase Inhibitors.

Authors:  Ahmed Bakr Abdelwahab; Eslam Reda El-Sawy; Atef G Hanna; Denyse Bagrel; Gilbert Kirsch
Journal:  Molecules       Date:  2022-04-07       Impact factor: 4.927

Review 5.  Menadione: a platform and a target to valuable compounds synthesis.

Authors:  Acácio S de Souza; Ruan Carlos B Ribeiro; Dora C S Costa; Fernanda P Pauli; David R Pinho; Matheus G de Moraes; Fernando de C da Silva; Luana da S M Forezi; Vitor F Ferreira
Journal:  Beilstein J Org Chem       Date:  2022-04-11       Impact factor: 2.544

Review 6.  Phosphorylation Dynamics of JNK Signaling: Effects of Dual-Specificity Phosphatases (DUSPs) on the JNK Pathway.

Authors:  Jain Ha; Eunjeong Kang; Jihye Seo; Sayeon Cho
Journal:  Int J Mol Sci       Date:  2019-12-06       Impact factor: 5.923
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.