Literature DB >> 19027021

Why did the NHE inhibitor clinical trials fail?

Elizabeth Murphy1, David G Allen.   

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Year:  2008        PMID： 19027021      PMCID： PMC2661870          DOI： 10.1016/j.yjmcc.2008.09.715

Source DB:  PubMed          Journal:  J Mol Cell Cardiol        ISSN： 0022-2828            Impact factor:   5.000


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  40 in total

1.  Sodium regulation during ischemia versus reperfusion and its role in injury.

Authors:  E Murphy; H Cross; C Steenbergen
Journal:  Circ Res       Date:  1999-06-25       Impact factor: 17.367

2.  Blocking Na(+)-H+ exchange by cariporide reduces Na(+)-overload in ischemia and is cardioprotective.

Authors:  M Hartmann; U K Decking
Journal:  J Mol Cell Cardiol       Date:  1999-11       Impact factor: 5.000

3.  Sodium-hydrogen exchange inhibition by cariporide to reduce the risk of ischemic cardiac events in patients undergoing coronary artery bypass grafting: results of the EXPEDITION study.

Authors:  Robert M Mentzer; Claus Bartels; Roberto Bolli; Steven Boyce; Gerald D Buckberg; Bernard Chaitman; Axel Haverich; John Knight; Philippe Menasché; M Lee Myers; Jose Nicolau; Maarten Simoons; Lars Thulin; Richard D Weisel
Journal:  Ann Thorac Surg       Date:  2008-04       Impact factor: 4.330

4.  Changes in intracellular Na+ and pH in rat heart during ischemia: role of Na+/H+ exchanger.

Authors:  C O Park; X H Xiao; D G Allen
Journal:  Am J Physiol       Date:  1999-05

5.  Role of Na(+)/H(+) exchanger during ischemia and preconditioning in the isolated rat heart.

Authors:  X H Xiao; D G Allen
Journal:  Circ Res       Date:  1999-10-15       Impact factor: 17.367

6.  The rise of [Na(+)] (i) during ischemia and reperfusion in the rat heart-underlying mechanisms.

Authors:  Iwan A Williams; Xiao-hui Xiao; Yue-kun Ju; David G Allen
Journal:  Pflugers Arch       Date:  2007-03-14       Impact factor: 3.657

7.  Cardioprotective effects of the Na(+)/H(+) exchange inhibitor cariporide in patients with acute anterior myocardial infarction undergoing direct PTCA.

Authors:  H J Rupprecht; J vom Dahl; W Terres; K M Seyfarth; G Richardt; H P Schultheibeta; M Buerke; F H Sheehan; H Drexler
Journal:  Circulation       Date:  2000-06-27       Impact factor: 29.690

8.  Slowly inactivating component of sodium current in ventricular myocytes is decreased by diabetes and partially inhibited by known Na(+)-H(+)Exchange blockers.

Authors:  S Chattou; A Coulombe; J Diacono; B Le Grand; G John; D Feuvray
Journal:  J Mol Cell Cardiol       Date:  2000-07       Impact factor: 5.000

9.  Na(+)/H(+) exchange inhibitor cariporide attenuates cell injury predominantly during ischemia and not at onset of reperfusion in porcine hearts with low residual blood flow.

Authors:  H H Klein; S Pich; R M Bohle; S Lindert-Heimberg; K Nebendahl
Journal:  Circulation       Date:  2000-10-17       Impact factor: 29.690

Review 10.  Targeting Na+/H+ exchanger regulation for cardiac protection: a RSKy approach?

Authors:  Metin Avkiran; Alexandra R Cook; Friederike Cuello
Journal:  Curr Opin Pharmacol       Date:  2008-01-28       Impact factor: 5.547
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  14 in total

1.  Riluzole protects against cardiac ischaemia and reperfusion damage via block of the persistent sodium current.

Authors:  S Weiss; D Benoist; E White; W Teng; D A Saint
Journal:  Br J Pharmacol       Date:  2010-07       Impact factor: 8.739

Review 2.  The role of comorbidities in cardioprotection.

Authors:  Michael N Sack; Elizabeth Murphy
Journal:  J Cardiovasc Pharmacol Ther       Date:  2011 Sep-Dec       Impact factor: 2.457

3.  The RSK Inhibitor BIX02565 Limits Cardiac Ischemia/Reperfusion Injury.

Authors:  Xi Shi; Margaret M O'Neill; Scott MacDonnell; Paul S Brookes; Chen Yan; Bradford C Berk
Journal:  J Cardiovasc Pharmacol Ther       Date:  2015-06-30       Impact factor: 2.457

Review 4.  What makes the mitochondria a killer? Can we condition them to be less destructive?

Authors:  Elizabeth Murphy; Charles Steenbergen
Journal:  Biochim Biophys Acta       Date:  2010-09-15

5.  Activation of microglia depends on Na+/H+ exchange-mediated H+ homeostasis.

Authors:  Yan Liu; Douglas B Kintner; Vishal Chanana; Jehad Algharabli; Xinzhi Chen; Yanqin Gao; Jun Chen; Peter Ferrazzano; Julie K Olson; Dandan Sun
Journal:  J Neurosci       Date:  2010-11-10       Impact factor: 6.167

Review 6.  Regulation of intracellular and mitochondrial sodium in health and disease.

Authors:  Elizabeth Murphy; David A Eisner
Journal:  Circ Res       Date:  2009-02-13       Impact factor: 17.367

Review 7.  Vascular remodeling in pulmonary hypertension.

Authors:  Larissa A Shimoda; Steven S Laurie
Journal:  J Mol Med (Berl)       Date:  2013-01-19       Impact factor: 4.599

Review 8.  Lung Circulation.

Authors:  Karthik Suresh; Larissa A Shimoda
Journal:  Compr Physiol       Date:  2016-03-15       Impact factor: 9.090

Review 9.  Targeting calcium transport in ischaemic heart disease.

Authors:  M A Hassan Talukder; Jay L Zweier; Muthu Periasamy
Journal:  Cardiovasc Res       Date:  2009-07-29       Impact factor: 10.787

10.  Mitochondrial NHE1: a newly identified target to prevent heart disease.

Authors:  Bernardo V Alvarez; María C Villa-Abrille
Journal:  Front Physiol       Date:  2013-06-28       Impact factor: 4.566
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