Literature DB >> 1902573

A post-transcriptional mechanism contributes to circadian cycling of a per-beta-galactosidase fusion protein.

L J Zwiebel1, P E Hardin, X Liu, J C Hall, M Rosbash.   

Abstract

The period gene (per) of Drosophila melanogaster affects circadian rhythms. Circadian fluctuations in per mRNA levels are thought to contribute to circadian fluctuations in per protein levels in the heads of adult flies. To address the mechanisms underlying these oscillatory phenomena, we have analyzed RNA and protein cycling from two per-beta-galactosidase fusion genes. These studies demonstrate that 5' noncoding sequences from per are sufficient to cause the fusion mRNA levels to cycle in a wild-type (rhythmic) background. Protein cycling requires additional sequences derived from the per coding region. The data suggest that there is a per-dependent posttranscriptional mechanism that is under circadian clock control required for per protein levels to fluctuate in a rhythmic fashion.

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Year:  1991        PMID： 1902573      PMCID： PMC51557          DOI： 10.1073/pnas.88.9.3882

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  18 in total

1.  Expression of the liver-enriched transcriptional activator protein DBP follows a stringent circadian rhythm.

Authors:  J Wuarin; U Schibler
Journal:  Cell       Date:  1990-12-21       Impact factor: 41.582

2.  Cyclin synthesis, modification and destruction during meiotic maturation of the starfish oocyte.

Authors:  N Standart; J Minshull; J Pines; T Hunt
Journal:  Dev Biol       Date:  1987-11       Impact factor: 3.582

3.  Fission yeast cdc25 is a cell-cycle regulated protein.

Authors:  B Ducommun; G Draetta; P Young; D Beach
Journal:  Biochem Biophys Res Commun       Date:  1990-02-28       Impact factor: 3.575

4.  A family of unusually spliced biologically active transcripts encoded by a Drosophila clock gene.

Authors:  Y Citri; H V Colot; A C Jacquier; Q Yu; J C Hall; D Baltimore; M Rosbash
Journal:  Nature       Date:  1987 Mar 5-11       Impact factor: 49.962

5.  Circadian regulation of bioluminescence in Gonyaulax involves translational control.

Authors:  D Morse; P M Milos; E Roux; J W Hastings
Journal:  Proc Natl Acad Sci U S A       Date:  1989-01       Impact factor: 11.205

Review 6.  The molecular biology of circadian rhythms.

Authors:  M Rosbash; J C Hall
Journal:  Neuron       Date:  1989-10       Impact factor: 17.173

7.  Spatial and temporal expression of the period gene in Drosophila melanogaster.

Authors:  X Liu; L Lorenz; Q N Yu; J C Hall; M Rosbash
Journal:  Genes Dev       Date:  1988-02       Impact factor: 11.361

8.  Antibodies to the period gene product of Drosophila reveal diverse tissue distribution and rhythmic changes in the visual system.

Authors:  K K Siwicki; C Eastman; G Petersen; M Rosbash; J C Hall
Journal:  Neuron       Date:  1988-04       Impact factor: 17.173

9.  Vasopressin mRNA in the suprachiasmatic nuclei: daily regulation of polyadenylate tail length.

Authors:  B G Robinson; D M Frim; W J Schwartz; J A Majzoub
Journal:  Science       Date:  1988-07-15       Impact factor: 47.728

10.  Expression of a Drosophila mRNA is under circadian clock control during pupation.

Authors:  L J Lorenz; J C Hall; M Rosbash
Journal:  Development       Date:  1989-12       Impact factor: 6.868
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  13 in total

1.  Circadian oscillations in period gene mRNA levels are transcriptionally regulated.

Authors:  P E Hardin; J C Hall; M Rosbash
Journal:  Proc Natl Acad Sci U S A       Date:  1992-12-15       Impact factor: 11.205

2.  A circadian enhancer mediates PER-dependent mRNA cycling in Drosophila melanogaster.

Authors:  H Hao; D L Allen; P E Hardin
Journal:  Mol Cell Biol       Date:  1997-07       Impact factor: 4.272

3.  Temporal and spatial expression patterns of transgenes containing increasing amounts of the Drosophila clock gene period and a lacZ reporter: mapping elements of the PER protein involved in circadian cycling.

Authors:  R Stanewsky; B Frisch; C Brandes; M J Hamblen-Coyle; M Rosbash; J C Hall
Journal:  J Neurosci       Date:  1997-01-15       Impact factor: 6.167

4.  Multiple circadian-regulated elements contribute to cycling period gene expression in Drosophila.

Authors:  R Stanewsky; C F Jamison; J D Plautz; S A Kay; J C Hall
Journal:  EMBO J       Date:  1997-08-15       Impact factor: 11.598

5.  Drosophila TRPA1 functions in temperature control of circadian rhythm in pacemaker neurons.

Authors:  Youngseok Lee; Craig Montell
Journal:  J Neurosci       Date:  2013-04-17       Impact factor: 6.167

6.  A novel circadian phenotype based on firefly luciferase expression in transgenic plants.

Authors:  A J Millar; S R Short; N H Chua; S A Kay
Journal:  Plant Cell       Date:  1992-09       Impact factor: 11.277

7.  Control of lhc gene transcription by the circadian clock in Chlamydomonas reinhardtii.

Authors:  S Hwang; D L Herrin
Journal:  Plant Mol Biol       Date:  1994-10       Impact factor: 4.076

8.  Temporal phosphorylation of the Drosophila period protein.

Authors:  I Edery; L J Zwiebel; M E Dembinska; M Rosbash
Journal:  Proc Natl Acad Sci U S A       Date:  1994-03-15       Impact factor: 11.205

9.  Control of the hypoxic response in Drosophila melanogaster by the basic helix-loop-helix PAS protein similar.

Authors:  Sofía Lavista-Llanos; Lázaro Centanin; Maximiliano Irisarri; Daniela M Russo; Jonathan M Gleadle; Silvia N Bocca; Mariana Muzzopappa; Peter J Ratcliffe; Pablo Wappner
Journal:  Mol Cell Biol       Date:  2002-10       Impact factor: 4.272

10.  Behavioral and molecular analyses suggest that circadian output is disrupted by disconnected mutants in D. melanogaster.

Authors:  P E Hardin; J C Hall; M Rosbash
Journal:  EMBO J       Date:  1992-01       Impact factor: 11.598
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