Literature DB >> 1902466

Analysis of a Corynebacterium glutamicum hom gene coding for a feedback-resistant homoserine dehydrogenase.

D J Reinscheid1, B J Eikmanns, H Sahm.   

Abstract

From a Corynebacterium glutamicum mutant possessing a homoserine dehydrogenase resistant to feedback inhibition by L-threonine, the corresponding gene (homFBR) was analyzed and compared with the wild-type hom gene. DNA fragment exchange experiments between both genes showed that a 0.23-kb region close to the 3' terminus of homFBR was responsible for deregulation. Nucleotide sequence analysis revealed a single transition from G to A in homFBR leading to replacement of glycine-378 by glutamate in the mutant homoserine dehydrogenase.

Entities:  

Mesh：

Substances：

Year:  1991        PMID： 1902466      PMCID： PMC207919          DOI： 10.1128/jb.173.10.3228-3230.1991

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  13 in total

Review 1.  The protein kinase family: conserved features and deduced phylogeny of the catalytic domains.

Authors:  S K Hanks; A M Quinn; T Hunter
Journal:  Science       Date:  1988-07-01       Impact factor: 47.728

2.  Homoserine dehydrogenase genetically desensitized to the feedback inhibition in Brevibacterium flavum.

Authors:  I Shiio; R Miyajima; S Nakamori
Journal:  J Biochem       Date:  1970-12       Impact factor: 3.387

3.  The complete nucleotide sequence of the ilvGMEDA operon of Escherichia coli K-12.

Authors:  R P Lawther; R C Wek; J M Lopes; R Pereira; B E Taillon; G W Hatfield
Journal:  Nucleic Acids Res       Date:  1987-03-11       Impact factor: 16.971

4.  The complete nucleotide sequence of the ilvGMEDA cluster of Escherichia coli K-12.

Authors:  J L Cox; B J Cox; V Fidanza; D H Calhoun
Journal:  Gene       Date:  1987       Impact factor: 3.688

5.  Nucleotide sequence of the metL gene of Escherichia coli. Its product, the bifunctional aspartokinase ii-homoserine dehydrogenase II, and the bifunctional product of the thrA gene, aspartokinase I-homoserine dehydrogenase I, derive from a common ancestor.

Authors:  M M Zakin; N Duchange; P Ferrara; G N Cohen
Journal:  J Biol Chem       Date:  1983-03-10       Impact factor: 5.157

6.  Cloning and nucleotide sequence of the Bacillus subtilis hom gene coding for homoserine dehydrogenase. Structural and evolutionary relationships with Escherichia coli aspartokinases-homoserine dehydrogenases I and II.

Authors:  C Parsot; G N Cohen
Journal:  J Biol Chem       Date:  1988-10-15       Impact factor: 5.157

7.  Regulation of enzymes of lysine biosynthesis in Corynebacterium glutamicum.

Authors:  J Cremer; C Treptow; L Eggeling; H Sahm
Journal:  J Gen Microbiol       Date:  1988-12

8.  DNA sequencing with chain-terminating inhibitors.

Authors:  F Sanger; S Nicklen; A R Coulson
Journal:  Proc Natl Acad Sci U S A       Date:  1977-12       Impact factor: 11.205

9.  Nucleotide sequence and fine structural analysis of the Corynebacterium glutamicum hom-thrB operon.

Authors:  O P Peoples; W Liebl; M Bodis; P J Maeng; M T Follettie; J A Archer; A J Sinskey
Journal:  Mol Microbiol       Date:  1988-01       Impact factor: 3.501

10.  Amplification of three threonine biosynthesis genes in Corynebacterium glutamicum and its influence on carbon flux in different strains.

Authors:  B J Eikmanns; M Metzger; D Reinscheid; M Kircher; H Sahm
Journal:  Appl Microbiol Biotechnol       Date:  1991-02       Impact factor: 4.813
View more
  9 in total

1.  Stable Expression of hom-1-thrB in Corynebacterium glutamicum and Its Effect on the Carbon Flux to Threonine and Related Amino Acids.

Authors:  D J Reinscheid; W Kronemeyer; L Eggeling; B J Eikmanns; H Sahm
Journal:  Appl Environ Microbiol       Date:  1994-01       Impact factor: 4.792

2.  Linking central metabolism with increased pathway flux: L-valine accumulation by Corynebacterium glutamicum.

Authors:  Eva Radmacher; Adela Vaitsikova; Udo Burger; Karin Krumbach; Hermann Sahm; Lothar Eggeling
Journal:  Appl Environ Microbiol       Date:  2002-05       Impact factor: 4.792

3.  Cloning of the trp gene cluster from a tryptophan-hyperproducing strain of Corynebacterium glutamicum: identification of a mutation in the trp leader sequence.

Authors:  D M Heery; L K Dunican
Journal:  Appl Environ Microbiol       Date:  1993-03       Impact factor: 4.792

4.  l-Isoleucine Production with Corynebacterium glutamicum: Further Flux Increase and Limitation of Export.

Authors:  S Morbach; H Sahm; L Eggeling
Journal:  Appl Environ Microbiol       Date:  1996-12       Impact factor: 4.792

5.  Functional and structural analyses of threonine dehydratase from Corynebacterium glutamicum.

Authors:  B Möckel; L Eggeling; H Sahm
Journal:  J Bacteriol       Date:  1992-12       Impact factor: 3.490

6.  Threonine-insensitive homoserine dehydrogenase from soybean: genomic organization, kinetic mechanism, and in vivo activity.

Authors:  Amy C Schroeder; Chuanmei Zhu; Srinivasa Rao Yanamadala; Rebecca E Cahoon; Kiani A J Arkus; Leia Wachsstock; Jeremy Bleeke; Hari B Krishnan; Joseph M Jez
Journal:  J Biol Chem       Date:  2009-11-06       Impact factor: 5.157

7.  Characterization of aspartate kinase and homoserine dehydrogenase from Corynebacterium glutamicum IWJ001 and systematic investigation of L-isoleucine biosynthesis.

Authors:  Xunyan Dong; Yue Zhao; Jianxun Zhao; Xiaoyuan Wang
Journal:  J Ind Microbiol Biotechnol       Date:  2016-03-31       Impact factor: 3.346

8.  Identification of glyA (encoding serine hydroxymethyltransferase) and its use together with the exporter ThrE to increase L-threonine accumulation by Corynebacterium glutamicum.

Authors:  Petra Simic; Juliane Willuhn; Hermann Sahm; Lothar Eggeling
Journal:  Appl Environ Microbiol       Date:  2002-07       Impact factor: 4.792

9.  High-throughput screening of a Corynebacterium glutamicum mutant library on genomic and metabolic level.

Authors:  Lorenz C Reimer; Jana Spura; Kerstin Schmidt-Hohagen; Dietmar Schomburg
Journal:  PLoS One       Date:  2014-02-04       Impact factor: 3.240
  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.