ETHNOPHARMACOLOGICAL RELEVANCE: Curatella americana L. (Dilleneaceae) is a medicinal plant very frequently cited as acting against gastrointestinal disorders in ethnopharmacological inventories of the Cerrado region of Brazil. AIM OF THE STUDY: The ethanolic extract (CEB) and infusion (BI) of Curatella americana bark were investigated for their ability to prevent and heal ulceration of the gastric mucosa. MATERIALS AND METHODS: The preventive and healing actions of Curatella americana were evaluated in experimental in vivo models in rodents that simulated this disease in human gastric mucosa. RESULTS: CEB significantly decreased the severity of gastric damage formation induced by the combination of several gastroprotective models (HCl/ethanol, indomethacin/bethanecol, absolute ethanol, stress and pylorus ligature). But, unlike CEB, the BI did not exert gastroprotective effect. The gastroprotective action of CEB involved antisecretory action, augmentation of gastric mucus (48%) and participation of endogenous sulfhydryl compounds that increase efficacy of barrier mucosa against injurious agents. CEB also presents effective healing action in chronic gastric disease (1.90+/-0.55 vs. 6.86+/-0.46 mm2)in the control) and its action mechanisms consisted of increasing the PGE2 (40%) and somatostatin levels (269%) while decreasing the gastrin level in rat plasma (79%). CONCLUSIONS: The gastroprotective effect and healing action of Curatella americana involved modulation of PGE2, somatostatin and gastrin levels, probably due to the presence of oligomeric and polymeric proanthocyanidins in the bark.
ETHNOPHARMACOLOGICAL RELEVANCE: Curatella americana L. (Dilleneaceae) is a medicinal plant very frequently cited as acting against gastrointestinal disorders in ethnopharmacological inventories of the Cerrado region of Brazil. AIM OF THE STUDY: The ethanolic extract (CEB) and infusion (BI) of Curatella americana bark were investigated for their ability to prevent and heal ulceration of the gastric mucosa. MATERIALS AND METHODS: The preventive and healing actions of Curatella americana were evaluated in experimental in vivo models in rodents that simulated this disease in humangastric mucosa. RESULTS:CEB significantly decreased the severity of gastric damage formation induced by the combination of several gastroprotective models (HCl/ethanol, indomethacin/bethanecol, absolute ethanol, stress and pylorus ligature). But, unlike CEB, the BI did not exert gastroprotective effect. The gastroprotective action of CEB involved antisecretory action, augmentation of gastric mucus (48%) and participation of endogenous sulfhydryl compounds that increase efficacy of barrier mucosa against injurious agents. CEB also presents effective healing action in chronic gastric disease (1.90+/-0.55 vs. 6.86+/-0.46 mm2)in the control) and its action mechanisms consisted of increasing the PGE2 (40%) and somatostatin levels (269%) while decreasing the gastrin level in rat plasma (79%). CONCLUSIONS: The gastroprotective effect and healing action of Curatella americana involved modulation of PGE2, somatostatin and gastrin levels, probably due to the presence of oligomeric and polymeric proanthocyanidins in the bark.
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Authors: Mayara Amoras Teles Fujishima; Dayse Maria Cunha Sá; Carolina Miranda de Sousa Lima; José Adolfo H M Bittencourt; Washington Luiz Assunção Pereira; Abraão de Jesus Barbosa Muribeca; Consuelo Yumiko Yoshioka E Silva; Milton Nascimento da Silva; Francisco Fábio Oliveira de Sousa; Cleydson B R Dos Santos; Jocivania Oliveira da Silva Journal: PLoS One Date: 2020-01-13 Impact factor: 3.240
Authors: Cleyton Eduardo Mendes de Toledo; Patrícia Regina Santos; João Carlos Palazzo de Mello; Benedito Prado Dias Filho; Celso Vataru Nakamura; Tânia Ueda-Nakamura Journal: Evid Based Complement Alternat Med Date: 2015-08-11 Impact factor: 2.629
Authors: Mayara Amoras Teles Fujishima; Nayara Dos Santos Raulino da Silva; Ryan da Silva Ramos; Elenilze Figueiredo Batista Ferreira; Kelton Luís Belém Dos Santos; Carlos Henrique Tomich de Paula da Silva; Jocivania Oliveira da Silva; Joaquín Maria Campos Rosa; Cleydson Breno Rodrigues Dos Santos Journal: Pharmaceuticals (Basel) Date: 2018-07-20