Literature DB >> 19019675

Beyond the MEK-pocket: can current MEK kinase inhibitors be utilized to synthesize novel type III NCKIs? Does the MEK-pocket exist in kinases other than MEK?

Haile Tecle1, Jianxing Shao, Yanhong Li, Michael Kothe, Steven Kazmirski, Julie Penzotti, Yuan-Hua Ding, Jeffrey Ohren, Deb Moshinsky, Rocco Coli, Nidhi Jhawar, Emilia Bora, Suzanne Jacques-O'Hagan, Joe Wu.   

Abstract

An approach and preliminary results for utilizing legacy MEK inhibitors as templates for a reiterative structural based design and synthesis of novel, type III NCKIs (non-classical kinase inhibitors) is described. Evidence is provided that the MEK-pocket or pockets closely related to it may exist in kinases other than MEK.

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Year:  2008        PMID： 19019675     DOI： 10.1016/j.bmcl.2008.10.108

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  11 in total

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