| Literature DB >> 19019645 |
T Iizuka1, H Sakai, H Moriyama, N Suto, M Nagai, D Bagchi.
Abstract
Forsythide (F1) isolated from the leaves of Forsythia viridissima (Oleaceae) showed vasorelaxant effects on norepinephrine (NE)-induced contraction of rat aorta with or without endothelium. This compound did not affect contraction induced by high concentration potassium (60 mM K(+)) and phorbol 12,13-diacetate, but inhibited NE-induced contraction in the presence of nicardipine. These results demonstrated the inhibitory effects of F1 on NE-induced vasocontraction presumably due to decrease of calcium influx from extracellular area, which was induced by NE.Entities:
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Year: 2008 PMID： 19019645 DOI： 10.1016/j.phymed.2008.09.011
Source DB: PubMed Journal: Phytomedicine ISSN： 0944-7113 Impact factor: 5.340