Vanessa L Jacoby1, Deborah Grady, George F Sawaya. 1. Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco, School of Medicine, San Francisco, CA 94115, USA. jacobyv@obgyn.ucsf.edu
Abstract
OBJECTIVE: The objective of the study was to examine the relationship between bilateral oophorectomy (BSO) and risk of coronary heart disease (CHD). STUDY DESIGN: We searched PubMed, EMBASE, meeting abstracts, and reference lists for studies that compared women with BSO at the time of hysterectomy with: (1) women with hysterectomy and ovarian conservation, (2) naturally menopausal women, (3) premenopausal women, or (4) women with no history of hysterectomy or BSO but unreported menopausal status. The primary outcome was fatal or nonfatal CHD. RESULTS: We reviewed 1956 citations. Seven observational studies met inclusion criteria. Heterogeneity among studies precluded formal metaanalysis. Four studies reported BSO increases risk for CHD but only in some subgroups of women or not in fully adjusted multivariate models. Three studies found no increased risk of CHD following BSO, but these studies had significant limitations. CONCLUSION: The existing evidence is inconclusive to determine the effect of BSO on risk of CHD.
OBJECTIVE: The objective of the study was to examine the relationship between bilateral oophorectomy (BSO) and risk of coronary heart disease (CHD). STUDY DESIGN: We searched PubMed, EMBASE, meeting abstracts, and reference lists for studies that compared women with BSO at the time of hysterectomy with: (1) women with hysterectomy and ovarian conservation, (2) naturally menopausal women, (3) premenopausal women, or (4) women with no history of hysterectomy or BSO but unreported menopausal status. The primary outcome was fatal or nonfatal CHD. RESULTS: We reviewed 1956 citations. Seven observational studies met inclusion criteria. Heterogeneity among studies precluded formal metaanalysis. Four studies reported BSO increases risk for CHD but only in some subgroups of women or not in fully adjusted multivariate models. Three studies found no increased risk of CHD following BSO, but these studies had significant limitations. CONCLUSION: The existing evidence is inconclusive to determine the effect of BSO on risk of CHD.
Authors: William H Parker; Michael S Broder; Zhimei Liu; Donna Shoupe; Cindy Farquhar; Jonathan S Berek Journal: Obstet Gynecol Date: 2005-08 Impact factor: 7.661
Authors: B J Naimark; A E Ready; J A Sawatzky; S Boreskie; J Ducas; D T Drinkwater; S Oosterveen Journal: Can J Cardiol Date: 1996-12 Impact factor: 5.223
Authors: Judith Hsia; David Barad; Karen Margolis; Rebecca Rodabough; Peter G McGovern; Marian C Limacher; Albert Oberman; Sylvia Smoller Journal: Am J Cardiol Date: 2003-08-01 Impact factor: 2.778
Authors: V M Miller; D M Black; E A Brinton; M J Budoff; M I Cedars; H N Hodis; R A Lobo; J E Manson; G R Merriam; F Naftolin; N Santoro; H S Taylor; S M Harman Journal: J Cardiovasc Transl Res Date: 2009-05-22 Impact factor: 4.132
Authors: Yamnia I Cortés; Nancy Reame; Cosmina Zeana; Haomiao Jia; David C Ferris; Elizabeth Shane; Michael T Yin Journal: J Womens Health (Larchmt) Date: 2016-09-09 Impact factor: 2.681
Authors: Lisa S Callegari; Kristen E Gray; Laurie C Zephyrin; Laura B Harrington; Megan R Gerber; Barbara B Cochrane; Julie C Weitlauf; Bevanne Bean-Mayberry; Lori A Bastian; Kristin M Mattocks; Sally G Haskell; Jodie G Katon Journal: Gerontologist Date: 2016-02
Authors: Catherine Kim; Mary Cushman; Yulia Khodneva; Lynda D Lisabeth; Suzanne Judd; Dawn O Kleindorfer; Virginia J Howard; Monika M Safford Journal: J Am Heart Assoc Date: 2015-07-01 Impact factor: 5.501
Authors: Lara Terra; Maartje J Hooning; Bernadette A M Heemskerk-Gerritsen; Marc van Beurden; Jeanine E Roeters van Lennep; Helena C van Doorn; Joanne A de Hullu; Constantijne Mom; Eleonora B L van Dorst; Marian J E Mourits; Brigitte F M Slangen; Katja N Gaarenstroom; M Carola Zillikens; Tim Leiner; Lizet van der Kolk; Margriet Collee; Marijke Wevers; Margreet G E M Ausems; Klaartje van Engelen; Lieke Pv Berger; Christi J van Asperen; Encarna B Gomez-Garcia; Irma van de Beek; Matti A Rookus; Michael Hauptmann; Eveline M Bleiker; Sanne B Schagen; Neil K Aaronson; Angela H E M Maas; Flora E van Leeuwen Journal: JMIR Res Protoc Date: 2021-01-22