OBJECTIVE: We tested the association between theory of mind (ToM) performance and structural changes in the brains of patients in the early course of schizophrenia. METHOD: Voxel-based morphometry (VBM) data of 18 patients with schizophrenia were compared with those of 21 controls. ToM skills were assessed by computerized faux pas (FP) tasks. RESULTS: Patients with schizophrenia performed significantly worse in FP tasks than healthy subjects. VBM revealed significantly reduced gray matter density in certain frontal, temporal and subcortical regions in patients with schizophrenia. Poor FP performance of schizophrenics correlated with gray matter reduction in the left orbitofrontal cortex and right temporal pole. CONCLUSION: Our data indicate an association between poor ToM performance and regional gray matter reduction in the left orbitofrontal cortex and right temporal pole shortly after the onset of schizophrenia.
OBJECTIVE: We tested the association between theory of mind (ToM) performance and structural changes in the brains of patients in the early course of schizophrenia. METHOD: Voxel-based morphometry (VBM) data of 18 patients with schizophrenia were compared with those of 21 controls. ToM skills were assessed by computerized faux pas (FP) tasks. RESULTS:Patients with schizophrenia performed significantly worse in FP tasks than healthy subjects. VBM revealed significantly reduced gray matter density in certain frontal, temporal and subcortical regions in patients with schizophrenia. Poor FP performance of schizophrenics correlated with gray matter reduction in the left orbitofrontal cortex and right temporal pole. CONCLUSION: Our data indicate an association between poor ToM performance and regional gray matter reduction in the left orbitofrontal cortex and right temporal pole shortly after the onset of schizophrenia.
Authors: Benjamin K Brent; Isabelle M Rosso; Heidi W Thermenos; Daphne J Holt; Stephen V Faraone; Nikos Makris; Ming T Tsuang; Larry J Seidman Journal: Schizophr Res Date: 2015-11-24 Impact factor: 4.939
Authors: William P Horan; Michael F Green; Michael DeGroot; Alan Fiske; Gerhard Hellemann; Kimmy Kee; Robert S Kern; Junghee Lee; Mark J Sergi; Kenneth L Subotnik; Catherine A Sugar; Joseph Ventura; Keith H Nuechterlein Journal: Schizophr Bull Date: 2011-03-07 Impact factor: 9.306
Authors: Laurie M McCormick; Michael C Brumm; Janelle N Beadle; Sergio Paradiso; Thoru Yamada; Nancy Andreasen Journal: Psychiatry Res Date: 2012-04-16 Impact factor: 3.222