| Literature DB >> 19014884 |
Andrew G Cole1, Axel Metzger, Marc-Raleigh Brescia, Lan-Ying Qin, Kenneth C Appell, Christopher T Brain, Allan Hallett, Pam Ganju, Alastair A Denholm, James R Wareing, Timothy J Ritchie, Gillian M Drake, Stuart J Bevan, Aisling MacGloinn, Andrew McBryde, Viral Patel, Paul J Oakley, Ximena Nunez, Hubert Gstach, Peter Schneider, John J Baldwin, Roland E Dolle, Edward McDonald, Ian Henderson.
Abstract
The synthesis and identification of sulfonamido-aryl ethers as potent bradykinin B1 receptor antagonists from a approximately 60,000 member encoded combinatorial library are reported. Two distinct series of compounds exhibiting different structure-activity relationships were identified in a bradykinin B1 whole-cell receptor-binding assay. Specific examples exhibit K(i) values of approximately 10nM.Entities:
Mesh：
Substances：
Year: 2008 PMID： 19014884 DOI： 10.1016/j.bmcl.2008.11.005
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823