Literature DB >> 1900925

Abnormal tau-reactive filaments in olfactory mucosa in biopsy specimens of patients with probable Alzheimer's disease.

M Tabaton1, S Cammarata, G L Mancardi, G Cordone, G Perry, C Loeb.   

Abstract

We immunocytochemically analyzed pieces of olfactory mucosa removed by biopsy in 8 patients with probable Alzheimer's disease (AD) and 6 age-matched controls, with tau and ubiquitin antisera. There were tau-reactive and, partially, ubiquitin-reactive dystrophic neurites in the lamina propria of olfactory mucosa in all AD cases. The tau-reactive neurites contained abnormal straight filaments, 15 to 18 nm in diameter, morphologically identical to those found in AD cerebral brain tissue obtained at autopsy. Tau and ubiquitin immunoreactivity were absent in controls. If these neuritic alterations are confirmed in a larger number of cases, analysis of olfactory mucosa may increase the current reliability of clinical diagnosis of AD.

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Year:  1991        PMID： 1900925     DOI： 10.1212/wnl.41.3.391

Source DB:  PubMed          Journal:  Neurology        ISSN： 0028-3878            Impact factor:   9.910


  6 in total

1.  Olfactory epithelium amyloid-beta and paired helical filament-tau pathology in Alzheimer disease.

Authors:  Steven E Arnold; Edward B Lee; Paul J Moberg; Lauren Stutzbach; Hala Kazi; Li-Ying Han; Virginia M Y Lee; John Q Trojanowski
Journal:  Ann Neurol       Date:  2010-04       Impact factor: 10.422

Review 2.  Application of olfactory tissue and its neural progenitors to schizophrenia and psychiatric research.

Authors:  Joëlle Lavoie; Akira Sawa; Koko Ishizuka
Journal:  Curr Opin Psychiatry       Date:  2017-05       Impact factor: 4.741

3.  The Olfactory Neural Epithelium As a Tool in Neuroscience.

Authors:  Joëlle Lavoie; Patricia Gassó Astorga; Hadar Segal-Gavish; YeeWen Candace Wu; Youjin Chung; Nicola G Cascella; Akira Sawa; Koko Ishizuka
Journal:  Trends Mol Med       Date:  2017-01-18       Impact factor: 11.951

Review 4.  At the interface of sensory and motor dysfunctions and Alzheimer's disease.

Authors:  Mark W Albers; Grover C Gilmore; Jeffrey Kaye; Claire Murphy; Arthur Wingfield; David A Bennett; Adam L Boxer; Aron S Buchman; Karen J Cruickshanks; Davangere P Devanand; Charles J Duffy; Christine M Gall; George A Gates; Ann-Charlotte Granholm; Takao Hensch; Roee Holtzer; Bradley T Hyman; Frank R Lin; Ann C McKee; John C Morris; Ronald C Petersen; Lisa C Silbert; Robert G Struble; John Q Trojanowski; Joe Verghese; Donald A Wilson; Shunbin Xu; Li I Zhang
Journal:  Alzheimers Dement       Date:  2014-07-09       Impact factor: 21.566

5.  Evaluation of the methoxy-X04 derivative BSC4090 for diagnosis of prodromal and early Alzheimer's disease from bioptic olfactory mucosa.

Authors:  Hannah Pellkofer; Friedrich Ihler; Bernhard G Weiss; Janina Trothe; Harindranath Kadavath; Monika Chongtham; Marcel Kunadt; Dietmar Riedel; Finn Lornsen; Petra Wilken; Claudia Bartels; Sina Hirschel; Sebastian G Russo; Elke Stransky; Lutz Trojan; Boris Schmidt; Eckhardt Mandelkow; Markus Zweckstetter; Martin Canis; Anja Schneider
Journal:  Eur Arch Psychiatry Clin Neurosci       Date:  2018-11-12       Impact factor: 5.270

6.  Neurofilament profile in olfactory mucosa of patients with a clinical diagnosis of Alzheimer's disease.

Authors:  S Kaakkola; J Palo; H Malmberg; R Sulkava; I Virtanen
Journal:  Virchows Arch       Date:  1994       Impact factor: 4.064
  6 in total

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