| Literature DB >> 19008110 |
Long Cui1, Phuong Thien Thuong, Hyun Sun Lee, Derek Tantoh Ndinteh, Joseph Tanyi Mbafor, Zacharias Tanee Fomum, Won Keun Oh.
Abstract
Twelve new flavanones bearing a 2,2-dimethylpyrano ring were isolated from a MeOH extract of the stem bark of Erythrina abyssinica. Their structures were determined on the basis of spectroscopic (UV, CD, 1D and 2D NMR, HRMS) and physico-chemical analyses. Compounds 1, 3, 5, 6, 8, and 9 exhibited inhibitory effects on the enzyme activity of PTP1B in an in vitro assay with IC(50) values ranging from 13.9+/-2.1 to 19.0+/-1.8 microM. These results suggest that prenyl and methoxy groups on the B ring contribute to the inhibitory activity of flavanones against PTP1B.Entities:
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Year: 2008 PMID： 19008110 DOI： 10.1016/j.bmc.2008.10.012
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641