Literature DB >> 19006393

Organocatalytic Michael addition of aldehydes to gamma-keto-alpha,beta-unsaturated esters. an efficient entry to versatile chiral building blocks.

Jing Wang1, Anqi Ma, Dawei Ma.   

Abstract

The diarylprolinol ether/HOAc-catalyzed Michael addition of aldehydes to gamma-keto-alpha,beta-unsaturated esters occurs in a highly regioselective and enantioselective manner. The adducts could easily be converted into synthetically useful cyclohexenones, cyclohexanones, piperidines, and gamma-lactones.

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Year:  2008        PMID： 19006393     DOI： 10.1021/ol802354u

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  3 in total

1.  Enamine/Carbene Cascade Catalysis in the Diastereo- and Enantioselective Synthesis of Functionalized Cyclopentanones.

Authors:  Kerem E Ozboya; Tomislav Rovis
Journal:  Chem Sci       Date:  2011-09-01       Impact factor: 9.825

2.  Evolution of a Short and Stereocontrolled Synthesis of (+)-7,20-Diisocyanoadociane.

Authors:  Philipp C Roosen; Alexander S Karns; Bryan D Ellis; Christopher D Vanderwal
Journal:  J Org Chem       Date:  2022-01-06       Impact factor: 4.198

Review 3.  Synthesis of indole derivatives as prevalent moieties present in selected alkaloids.

Authors:  Majid M Heravi; Zahra Amiri; Kosar Kafshdarzadeh; Vahideh Zadsirjan
Journal:  RSC Adv       Date:  2021-10-15       Impact factor: 4.036
  3 in total

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