| Literature DB >> 19005624 |
Takatoshi Aoki1, Toshihiro Miyamoto2, Shuro Yoshida1, Asataro Yamamoto1, Takuji Yamauchi1, Goichi Yoshimoto1, Yasuo Mori1, Kenjiro Kamezaki1, Hiromi Iwasaki3, Katsuto Takenaka1, Naoki Harada1, Koji Nagafuji1, Takanori Teshima3, Koichi Akashi1.
Abstract
We report a 29-year-old Japanese male with acute myelogenous leukemia (AML)-M4 with a cryptic t(7;11)(p15;p15), in which a chimeric NUP98-HOXA9 fusion was detected by polymerase chain reaction analysis and a chromosomal analysis showed 46,XY. The patient received intensive chemotherapy and underwent autologous stem cell transplantation, and remission was confirmed by the disappearance of NUP98-HOXA9. However, 6 months after transplantation, the patient relapsed; NUP98-HOXA9 was detected again and karyotypic analysis revealed 46,XY, t(1;21)(p32;q22). Fluorescent in situ hybridization (FISH) analysis using an AML1-ETO translocation dual probe, showed that the 21q22 breakpoint involved AML1 locus. A retrospective FISH analysis showed that t(1;21) was absent at onset. This is the first reported case with AML who had a cryptic t(7;11)(p15;p15), and additionally acquired t(1;21)(p32;q22) at relapse.Entities:
Mesh：
Substances：
Year: 2008 PMID： 19005624 DOI： 10.1007/s12185-008-0198-9
Source DB: PubMed Journal: Int J Hematol ISSN： 0925-5710 Impact factor: 2.490