Literature DB >> 19004630

Dihydropyrazolopyrimidine inhibitors of K(V)1.5 (I(Kur)).

Wayne Vaccaro1, Tram Huynh, John Lloyd, Karnail Atwal, Heather J Finlay, Paul Levesque, Mary Lee Conder, Tonya Jenkins-West, Hong Shi, Lucy Sun.   

Abstract

A series of dihydropyrazolopyrimidine inhibitors of K(V)1.5 (I(Kur)) have been identified. The synthesis, structure-activity relationships and selectivity against several other ion channels are described.

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Year:  2008        PMID: 19004630     DOI: 10.1016/j.bmcl.2008.10.099

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  3 in total

Review 1.  Chemistry and biology of multicomponent reactions.

Authors:  Alexander Dömling; Wei Wang; Kan Wang
Journal:  Chem Rev       Date:  2012-03-22       Impact factor: 60.622

2.  Rational Design and Synthesis of 3-Morpholine Linked Aromatic-Imino-1H-Indoles as Novel Kv1.5 Channel Inhibitors Sharing Vasodilation Effects.

Authors:  Wei Qin; Yi-Heng Li; Jing Tong; Jie Wu; Dong Zhao; Hui-Jin Li; Lu Xing; Chun-Xia He; Xin Zhou; Peng-Quan Li; Ge Meng; Shao-Ping Wu; Hui-Ling Cao
Journal:  Front Mol Biosci       Date:  2022-01-24

3.  Dihydropyrimidinones: efficient one-pot green synthesis using Montmorillonite-KSF and evaluation of their cytotoxic activity.

Authors:  Saleem Farooq; Fahad A Alharthi; Ali Alsalme; Aashiq Hussain; Bashir A Dar; Abid Hamid; S Koul
Journal:  RSC Adv       Date:  2020-11-23       Impact factor: 4.036

  3 in total

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