X Y Hu1, Y M Xu, Q Fu, J J Yu, J Huang. 1. Department of Urology, Shanghai Jiaotong University Affiliated 6th People's Hospital, Shanghai Jiaotong University, Shanghai, PR China.
Abstract
AIMS: To characterize aspects of Nedd4L in prostate cancer (PC) by assessing its expression in hyperplastic and malignant prostate tissue, and to correlate findings with PC histologic grade. MATERIALS AND METHODS: Radical prostatectomy (RP) specimens from 56 patients with clinically localized PC, and benign prostatic hyperplasia (BPH) transurethral resection specimens from 31 patients, were assessed for Nedd4L expression using immunohistochemistry. RESULTS: Nedd4L (P<0.001) expressions were significantly decreased in PC compared to benign prostate tissue. Furthermore, downregulation of Nedd4L (P<0.05) expression correlated with increasing Gleason score. CONCLUSIONS: These data suggest that prostate cancer cells in vivo may need Nedd4L expression to regulate TGF-beta1 signaling, and that Nedd4L expression might be involved in prostate cancer development.
AIMS: To characterize aspects of Nedd4L in prostate cancer (PC) by assessing its expression in hyperplastic and malignant prostate tissue, and to correlate findings with PC histologic grade. MATERIALS AND METHODS: Radical prostatectomy (RP) specimens from 56 patients with clinically localized PC, and benign prostatic hyperplasia (BPH) transurethral resection specimens from 31 patients, were assessed for Nedd4L expression using immunohistochemistry. RESULTS:Nedd4L (P<0.001) expressions were significantly decreased in PC compared to benign prostate tissue. Furthermore, downregulation of Nedd4L (P<0.05) expression correlated with increasing Gleason score. CONCLUSIONS: These data suggest that prostate cancer cells in vivo may need Nedd4L expression to regulate TGF-beta1 signaling, and that Nedd4L expression might be involved in prostate cancer development.
Authors: Anthony D Krentz; Mark W Murphy; Teng Zhang; Aaron L Sarver; Sanjay Jain; Michael D Griswold; Vivian J Bardwell; David Zarkower Journal: Dev Biol Date: 2013-03-06 Impact factor: 3.582