John P Geisler1, Kelly J Manahan. 1. Indiana Women's Oncology, Division of Gynecologic Oncology, St. Vincent Hospitals, Indianapolis, IN 46260, USA. jgeisler@indianawomensoncology.com
Abstract
BACKGROUND: Vulvar Paget's disease is a relatively rare gynecologic neoplasm that is problematic because of its propensity to recur. CASE: An 80-year-old woman was found to have recurrent Paget's disease of the vulva. She was initially diagnosed 12 years previously and had had multiple resections for the disease. She was found to have histologically proven Paget's disease and underwent a course of topical immune modulator therapy with imiquimod. Biopsy proved histologic regression of the disease progress. The patient remained without recurrence 12 months after therapy. CONCLUSION: In select patients imiquimod may be used to treat or facilitate treatment of vulvar Paget's disease.
BACKGROUND:Vulvar Paget's disease is a relatively rare gynecologic neoplasm that is problematic because of its propensity to recur. CASE: An 80-year-old woman was found to have recurrent Paget's disease of the vulva. She was initially diagnosed 12 years previously and had had multiple resections for the disease. She was found to have histologically proven Paget's disease and underwent a course of topical immune modulator therapy with imiquimod. Biopsy proved histologic regression of the disease progress. The patient remained without recurrence 12 months after therapy. CONCLUSION: In select patients imiquimod may be used to treat or facilitate treatment of vulvar Paget's disease.
Authors: Cristina Anton; Arthur Vicentini da Costa Luiz; Filomena Marino Carvalho; Edmund Chada Baracat; Jesus Paula Carvalho Journal: Clinics (Sao Paulo) Date: 2011 Impact factor: 2.365