| Literature DB >> 1900274 |
Y Inoue1, Y Kashima, K Aizawa, K Hatakeyama.
Abstract
A new cell line (RCN-9) was established in culture from a transplantable rat colon adenocarcinoma, which was induced in the colon of a male Fischer F344 rat by subcutaneous administration of 1,2-dimethylhydrazine. When RCN-9 cells were injected subcutaneously or into the cecal subserosa of syngeneic rats, carcinomas with progressive growth were obtained and the development of lung (63.6%) and liver (40.0%) metastases, respectively, ensued. Antitumor effects of 5-fluorouracil (5-FU), adriamycin (ADM) and mitomycin C (MMC) against RCN-9 were examined in vivo and in vitro. 5-FU and ADM had antitumor effects both in vivo and in vitro; MMC had antitumor effects in vitro. These results show that the RCN-9 cell line can be used both as a model to study mechanisms of metastasis from colon carcinoma and as a model in chemotherapeutic studies of metastatic disease from colon carcinoma.Entities:
Mesh：
Year: 1991 PMID： 1900274 PMCID： PMC5918205 DOI： 10.1111/j.1349-7006.1991.tb01751.x
Source DB: PubMed Journal: Jpn J Cancer Res ISSN： 0910-5050