OBJECTIVES: (a) The development of a novel analysis method, named Dynamic pixel intensity Histogram Analysis (DHA) allowing for pixel intensity-histogram-model-parameter fitting of arbitrary-shaped regions defined in dynamic-susceptibility-contrast-enhanced (DSCE) difference MR-image time-series, and (b) its prospective application and evaluation for glioma grading. MATERIALS AND METHODS: For each difference-image, pixel intensity histograms of arbitrary-shaped ROIs were computed and fitted using the Levenberg-Marquardt algorithm. Time-dependent histogram center-position- and width-parameters are computed during bolus-passage. The method was applied to 25 patients with low and high grade gliomas. RESULTS: During bolus outflow-time, histogram-center-position-parameter and histogram-width-parameter reach highest significance levels and discriminate gliomas of different grades. The histogram center-position-parameter discriminated grade-II from grade-III, grade-II from grade-IV but not grade-III from grade-IV. The observed histogram width-parameters discriminated grade-II from grade-III (P < 0.00022), grade-II from grade-IV (P <8.3 10), and grade-III from grade-IV (P < 0.00063). CONCLUSIONS: DHA is a easy-to-use method for glioma grading; the histogram width parameter is best indicator for histologic grade.
OBJECTIVES: (a) The development of a novel analysis method, named Dynamic pixel intensity Histogram Analysis (DHA) allowing for pixel intensity-histogram-model-parameter fitting of arbitrary-shaped regions defined in dynamic-susceptibility-contrast-enhanced (DSCE) difference MR-image time-series, and (b) its prospective application and evaluation for glioma grading. MATERIALS AND METHODS: For each difference-image, pixel intensity histograms of arbitrary-shaped ROIs were computed and fitted using the Levenberg-Marquardt algorithm. Time-dependent histogram center-position- and width-parameters are computed during bolus-passage. The method was applied to 25 patients with low and high grade gliomas. RESULTS: During bolus outflow-time, histogram-center-position-parameter and histogram-width-parameter reach highest significance levels and discriminate gliomas of different grades. The histogram center-position-parameter discriminated grade-II from grade-III, grade-II from grade-IV but not grade-III from grade-IV. The observed histogram width-parameters discriminated grade-II from grade-III (P < 0.00022), grade-II from grade-IV (P <8.3 10), and grade-III from grade-IV (P < 0.00063). CONCLUSIONS:DHA is a easy-to-use method for glioma grading; the histogram width parameter is best indicator for histologic grade.
Authors: Gregory A Christoforidis; Ming Yang; Marinos S Kontzialis; Douglas G Larson; Amir Abduljalil; Michelle Basso; Weilian Yang; Abhik Ray-Chaudhury; Johannes Heverhagen; Michael V Knopp; Rolf F Barth Journal: Invest Radiol Date: 2009-07 Impact factor: 6.016
Authors: Sofie Van Cauter; Frederik De Keyzer; Diana M Sima; Anca Croitor Sava; Felice D'Arco; Jelle Veraart; Ronald R Peeters; Alexander Leemans; Stefaan Van Gool; Guido Wilms; Philippe Demaerel; Sabine Van Huffel; Stefan Sunaert; Uwe Himmelreich Journal: Neuro Oncol Date: 2014-07 Impact factor: 12.300
Authors: Christian Philipp Kamm; Marwan El-Koussy; Sebastian Humpert; Oliver Findling; Ferdinand von Bredow; Yuliya Burren; Guido Schwegler; Dagmar Schött; Filippo Donati; Martin Müller; Norbert Goebels; Felix Müller; Johannes Slotboom; Barbara Tettenborn; Ludwig Kappos; Yvonne Naegelin; Heinrich Paul Mattle Journal: J Neurol Date: 2012-05-09 Impact factor: 4.849
Authors: Rajeev Kumar Verma; Johannes Slotboom; Mirjam Rachel Heldner; Mirjam Rahel Heldner; Frauke Kellner-Weldon; Raimund Kottke; Christoph Ozdoba; Christian Weisstanner; Christian Philipp Kamm; Roland Wiest Journal: PLoS One Date: 2013-07-16 Impact factor: 3.240
Authors: Christian P Kamm; Marwan El-Koussy; Sebastian Humpert; Oliver Findling; Yuliya Burren; Guido Schwegler; Filippo Donati; Martin Müller; Felix Müller; Johannes Slotboom; Ludwig Kappos; Yvonne Naegelin; Heinrich P Mattle Journal: PLoS One Date: 2014-01-30 Impact factor: 3.240
Authors: Nicole Porz; Stefan Bauer; Alessia Pica; Philippe Schucht; Jürgen Beck; Rajeev Kumar Verma; Johannes Slotboom; Mauricio Reyes; Roland Wiest Journal: PLoS One Date: 2014-05-07 Impact factor: 3.240
Authors: Rajeev K Verma; Johannes Slotboom; Cäcilia Locher; Mirjam R Heldner; Christian Weisstanner; Eugenio Abela; Frauke Kellner-Weldon; Martin Zbinden; Christian P Kamm; Roland Wiest Journal: Biomed Res Int Date: 2016-01-13 Impact factor: 3.411