Literature DB >> 19000829

Autophagy gives a nod and a wink to the inflammasome and Paneth cells in Crohn's disease.

Vojo Deretic1, Sharon Master, Sudha Singh.   

Abstract

Recent genome-wide association studies have linked polymorphisms in two atophagy genes, Atg16L1 and IRGM, with Crohn's Disease. Now, experiments with Atg16L1 transgenic mice indicate multiple roles for autophagy in inflammatory bowel disease via effects on Paneth cells, a runaway inflammasome, and the proinflammatory cytokine IL-1beta.

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Year:  2008        PMID： 19000829      PMCID： PMC3725296          DOI： 10.1016/j.devcel.2008.10.009

Source DB:  PubMed          Journal:  Dev Cell        ISSN： 1534-5807            Impact factor:   12.270


  10 in total

Review 1.  Intracellular NOD-like receptors in host defense and disease.

Authors:  Thirumala-Devi Kanneganti; Mohamed Lamkanfi; Gabriel Núñez
Journal:  Immunity       Date:  2007-10       Impact factor: 31.745

Review 2.  Unravelling the pathogenesis of inflammatory bowel disease.

Authors:  R J Xavier; D K Podolsky
Journal:  Nature       Date:  2007-07-26       Impact factor: 49.962

3.  Toll-like receptors control autophagy.

Authors:  Mónica A Delgado; Rasha A Elmaoued; Alexander S Davis; George Kyei; Vojo Deretic
Journal:  EMBO J       Date:  2008-03-13       Impact factor: 11.598

4.  The Atg16L complex specifies the site of LC3 lipidation for membrane biogenesis in autophagy.

Authors:  Naonobu Fujita; Takashi Itoh; Hiroko Omori; Mitsunori Fukuda; Takeshi Noda; Tamotsu Yoshimori
Journal:  Mol Biol Cell       Date:  2008-03-05       Impact factor: 4.138

5.  Human IRGM induces autophagy to eliminate intracellular mycobacteria.

Authors:  Sudha B Singh; Alexander S Davis; Gregory A Taylor; Vojo Deretic
Journal:  Science       Date:  2006-08-03       Impact factor: 47.728

6.  Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production.

Authors:  Tatsuya Saitoh; Naonobu Fujita; Myoung Ho Jang; Satoshi Uematsu; Bo-Gie Yang; Takashi Satoh; Hiroko Omori; Takeshi Noda; Naoki Yamamoto; Masaaki Komatsu; Keiji Tanaka; Taro Kawai; Tohru Tsujimura; Osamu Takeuchi; Tamotsu Yoshimori; Shizuo Akira
Journal:  Nature       Date:  2008-10-05       Impact factor: 49.962

7.  A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells.

Authors:  Ken Cadwell; John Y Liu; Sarah L Brown; Hiroyuki Miyoshi; Joy Loh; Jochen K Lennerz; Chieko Kishi; Wumesh Kc; Javier A Carrero; Steven Hunt; Christian D Stone; Elizabeth M Brunt; Ramnik J Xavier; Barry P Sleckman; Ellen Li; Noboru Mizushima; Thaddeus S Stappenbeck; Herbert W Virgin
Journal:  Nature       Date:  2008-10-05       Impact factor: 49.962

8.  Mechanism of IL-1beta-induced increase in intestinal epithelial tight junction permeability.

Authors:  Rana Al-Sadi; Dongmei Ye; Karol Dokladny; Thomas Y Ma
Journal:  J Immunol       Date:  2008-04-15       Impact factor: 5.422

9.  Impaired autophagy of an intracellular pathogen induced by a Crohn's disease associated ATG16L1 variant.

Authors:  Petric Kuballa; Alan Huett; John D Rioux; Mark J Daly; Ramnik J Xavier
Journal:  PLoS One       Date:  2008-10-13       Impact factor: 3.240

Review 10.  Unveiling the roles of autophagy in innate and adaptive immunity.

Authors:  Beth Levine; Vojo Deretic
Journal:  Nat Rev Immunol       Date:  2007-10       Impact factor: 53.106
  10 in total
  13 in total

1.  Regulation of macrophage motility by Irgm1.

Authors:  Stanley C Henry; Maria Traver; Xiaojou Daniell; Maanasa Indaram; Tim Oliver; Gregory A Taylor
Journal:  J Leukoc Biol       Date:  2009-11-17       Impact factor: 4.962

Review 2.  Gene-environment interactions in inflammatory bowel disease: microbiota and genes.

Authors:  Marian C Aldhous
Journal:  Frontline Gastroenterol       Date:  2012-05-21

3.  Autophagy genes protect against Salmonella typhimurium infection and mediate insulin signaling-regulated pathogen resistance.

Authors:  Kailiang Jia; Collin Thomas; Muhammad Akbar; Qihua Sun; Beverley Adams-Huet; Christopher Gilpin; Beth Levine
Journal:  Proc Natl Acad Sci U S A       Date:  2009-08-10       Impact factor: 11.205

Review 4.  Links between autophagy, innate immunity, inflammation and Crohn's disease.

Authors:  Vojo Deretic
Journal:  Dig Dis       Date:  2009-09-24       Impact factor: 2.404

5.  Intestinal epithelial vitamin D receptor deletion leads to defective autophagy in colitis.

Authors:  Shaoping Wu; Yong-Guo Zhang; Rong Lu; Yinglin Xia; David Zhou; Elaine O Petrof; Erika C Claud; Di Chen; Eugene B Chang; Geert Carmeliet; Jun Sun
Journal:  Gut       Date:  2014-07-30       Impact factor: 23.059

6.  SCFAs induce autophagy in intestinal epithelial cells and relieve colitis by stabilizing HIF-1α.

Authors:  Chao Zhou; Liangzi Li; Teming Li; Lihua Sun; Jiuheng Yin; Haidi Guan; Liucan Wang; Hongbing Zhu; Peng Xu; Xin Fan; Baifa Sheng; Weidong Xiao; Yuan Qiu; Hua Yang
Journal:  J Mol Med (Berl)       Date:  2020-07-22       Impact factor: 4.599

7.  Inflammasome-independent modulation of cytokine response by autophagy in human cells.

Authors:  Tania O Crişan; Theo S Plantinga; Frank L van de Veerdonk; Marius F Farcaş; Monique Stoffels; Bart-Jan Kullberg; Jos W M van der Meer; Leo A B Joosten; Mihai G Netea
Journal:  PLoS One       Date:  2011-04-07       Impact factor: 3.240

Review 8.  Impact of Paneth Cell Autophagy on Inflammatory Bowel Disease.

Authors:  Shu-Ling Wang; Bo-Zong Shao; Sheng-Bing Zhao; Jun Fang; Lun Gu; Chao-Yu Miao; Zhao-Shen Li; Yu Bai
Journal:  Front Immunol       Date:  2018-04-05       Impact factor: 7.561

9.  Regulation of ATG4B stability by RNF5 limits basal levels of autophagy and influences susceptibility to bacterial infection.

Authors:  Ersheng Kuang; Cheryl Y M Okumura; Sharon Sheffy-Levin; Tal Varsano; Vincent Chih-Wen Shu; Jianfei Qi; Ingrid R Niesman; Huei-Jiun Yang; Carlos López-Otín; Wei Yuan Yang; John C Reed; Limor Broday; Victor Nizet; Ze'ev A Ronai
Journal:  PLoS Genet       Date:  2012-10-18       Impact factor: 5.917

10.  Genetic variants associated with Crohn's disease.

Authors:  Sonia Michail; Gilberto Bultron; R William Depaolo
Journal:  Appl Clin Genet       Date:  2013-07-16
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