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Literature DB >> 18997785

Genetic variation in the KIF1B locus influences susceptibility to multiple sclerosis.

Yurii S Aulchenko¹, Ilse A Hoppenbrouwers, Sreeram V Ramagopalan, Linda Broer, Naghmeh Jafari, Jan Hillert, Jenny Link, Wangko Lundström, Eva Greiner, A Dessa Sadovnick, Dirk Goossens, Christine Van Broeckhoven, Jurgen Del-Favero, George C Ebers, Ben A Oostra, Cornelia M van Duijn, Rogier Q Hintzen.

Abstract

The few loci associated with multiple sclerosis (MS) are all related to immune function. We report a GWA study identifying a new locus replicated in 2,679 cases and 3,125 controls. An rs10492972[C] variant located in the KIF1B gene was associated with MS with an odds ratio of 1.35 (P = 2.5 x 10(-10)). KIF1B is a neuronally expressed gene plausibly implicated in the irreversible axonal loss characterizing MS in the long term.

Entities: Chemical Disease Gene Mutation Species

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Year: 2008 PMID： 18997785 DOI： 10.1038/ng.251

Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330

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Cited

79 in total

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Journal: BMC Med Genet Date: 2010-04-28 Impact factor: 2.103

7. Lack of support for association between the KIF1B rs10492972[C] variant and multiple sclerosis.

Authors: David R Booth; Robert N Heard; Graeme J Stewart; Mathew Cox; Rodney J Scott; Jeannette Lechner-Scott; An Goris; Rita Dobosi; Bénédicte Dubois; Janna Saarela; Virpi Leppä; Leena Peltonen; Tuula Pirttila; Isabelle Cournu-Rebeix; Bertrand Fontaine; Laura Bergamaschi; Sandra D'Alfonso; Maurizio Leone; Aslaug R Lorentzen; Hanne F Harbo; Elisabeth G Celius; Anne Spurkland; Jenny Link; Ingrid Kockum; Tomas Olsson; Jan Hillert; Maria Ban; Amie Baker; Anu Kemppinen; Stephen Sawcer; Alastair Compston; Neil P Robertson; Philip L De Jager; David A Hafler; Lisa F Barcellos; Adrian J Ivinson; Jacob L McCauley; Margaret A Pericak-Vance; Jorge R Oksenberg; Stephen L Hauser; David Sexton; Jonathan Haines
Journal: Nat Genet Date: 2010-06 Impact factor: 38.330