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Literature DB >> 18996119

Redox properties of the A-domain of the HMGB1 protein.

Debashish Sahu¹, Priyanka Debnath, Yuki Takayama, Junji Iwahara.

Abstract

The High Mobility Group B1 (HMGB1) protein plays important roles in both intracellular (reductive) and extracellular (oxidative) environments. We have carried out quantitative investigations of the redox chemistry involving Cys22 and Cys44 of the HMGB1 A-domain, which form an intramolecular disulfide bond. Using NMR spectroscopy, we analyzed the real-time kinetics of the redox reactions for the A-domain in glutathione and thioredoxin systems, and also determined the standard redox potential. Thermodynamic experiments showed that the Cys22-Cys44 disulfide bond stabilizes the folded state of the protein. These data suggest that the oxidized HMGB1 may accumulate even in cells under oxidative stress.

Entities: Chemical Disease Gene Species

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Year: 2008 PMID： 18996119 PMCID： PMC2614879 DOI： 10.1016/j.febslet.2008.09.061

Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124

16 in total

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Journal: EMBO Rep Date: 2002-09-13 Impact factor: 8.807

8. Characterization of nonspecific protein-DNA interactions by 1H paramagnetic relaxation enhancement.

Authors: Junji Iwahara; Charles D Schwieters; G Marius Clore
Journal: J Am Chem Soc Date: 2004-10-13 Impact factor: 15.419

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Authors: Marco E Bianchi; Angelo A Manfredi
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23 in total

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5. Real-time kinetics of high-mobility group box 1 (HMGB1) oxidation in extracellular fluids studied by in situ protein NMR spectroscopy.

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Review 6. The HMGB1-RAGE Inflammatory Pathway: Implications for Brain Injury-Induced Pulmonary Dysfunction.

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7. Identification of a functional interaction of HMGB1 with Receptor for Advanced Glycation End-products in a model of neuropathic pain.

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Journal: Brain Behav Immun Date: 2014-07-08 Impact factor: 7.217

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Authors: Michael C Yi; Chaitan Khosla
Journal: Annu Rev Chem Biomol Eng Date: 2016-03-17 Impact factor: 11.059

10. Enzyme activity of phosphatase of regenerating liver is controlled by the redox environment and its C-terminal residues.

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Journal: Biochemistry Date: 2009-05-26 Impact factor: 3.162