Literature DB >> 18995919

Effective avoidance of a functional spect-perfused lung using intensity modulated radiotherapy (IMRT) for non-small cell lung cancer (NSCLC): an update of a planning study.

Konstantin Lavrenkov1, Shalini Singh, Judith A Christian, Mike Partridge, Elena Nioutsikou, Gary Cook, James L Bedford, Michael Brada.   

Abstract

IMRT and 3-dimensional conformal radiotherapy (3-DCRT) plans of 25 patients with non-small cell lung (NSCLC) were compared in terms of planning target volume (PTV) coverage and sparing of functional lung (FL) defined by a SPECT perfusion scan. IMRT resulted in significant reduction of functional V(20) and mean lung dose in stage III patients with inhomogeneous hypoperfusion. If the dose to FL is shown to be the determinant of lung toxicity, IMRT would allow for effective dose escalation by specific avoidance of functional lung.

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Year:  2008        PMID： 18995919     DOI： 10.1016/j.radonc.2008.10.005

Source DB:  PubMed          Journal:  Radiother Oncol        ISSN： 0167-8140            Impact factor:   6.280


  9 in total

Review 1.  Imaging techniques for tumour delineation and heterogeneity quantification of lung cancer: overview of current possibilities.

Authors:  Wouter van Elmpt; Catharina M L Zegers; Marco Das; Dirk De Ruysscher
Journal:  J Thorac Dis       Date:  2014-04       Impact factor: 2.895

Review 2.  Functional and molecular image guidance in radiotherapy treatment planning optimization.

Authors:  Shiva K Das; Randall K Ten Haken
Journal:  Semin Radiat Oncol       Date:  2011-04       Impact factor: 5.934

3.  Changes in global function and regional ventilation and perfusion on SPECT during the course of radiotherapy in patients with non-small-cell lung cancer.

Authors:  Shuanghu Tiger Yuan; Kirk A Frey; Milton D Gross; James A Hayman; Doug Arenberg; Xu-Wei Cai; Nithya Ramnath; Khaled Hassan; Jean Moran; Avraham Eisbruch; Randall K Ten Haken; Feng-Ming Spring Kong
Journal:  Int J Radiat Oncol Biol Phys       Date:  2011-12-22       Impact factor: 7.038

4.  Changes in functional lung regions during the course of radiation therapy and their potential impact on lung dosimetry for non-small cell lung cancer.

Authors:  Xue Meng; Kirk Frey; Martha Matuszak; Stanton Paul; Randall Ten Haken; Jinming Yu; Feng-Ming Spring Kong
Journal:  Int J Radiat Oncol Biol Phys       Date:  2014-05-01       Impact factor: 7.038

5.  Functional image-based radiotherapy planning for non-small cell lung cancer: A simulation study.

Authors:  Emma L Bates; Christopher M Bragg; Jim M Wild; Matthew Q F Hatton; Rob H Ireland
Journal:  Radiother Oncol       Date:  2009-06-22       Impact factor: 6.280

6.  Priority-driven plan optimization in locally advanced lung patients based on perfusion SPECT imaging.

Authors:  Martha M Matuszak; Charles Matrosic; David Jarema; Daniel L McShan; Matthew H Stenmark; Dawn Owen; Shruti Jolly; Feng-Ming Spring Kong; Randall K Ten Haken
Journal:  Adv Radiat Oncol       Date:  2016-10-29

7.  Functional perfusion image guided radiation treatment planning for locally advanced lung cancer.

Authors:  Katherina P Farr; Katrina West; Roland Yeghiaian-Alvandi; David Farlow; Rachel Stensmyr; Andrew Chicco; Eric Hau
Journal:  Phys Imaging Radiat Oncol       Date:  2019-09-20

8.  Functional lung avoidance for individualized radiotherapy (FLAIR): study protocol for a randomized, double-blind clinical trial.

Authors:  Douglas A Hoover; Dante Pi Capaldi; Khadija Sheikh; David A Palma; George B Rodrigues; A Rashid Dar; Edward Yu; Brian Dingle; Mark Landis; Walter Kocha; Michael Sanatani; Mark Vincent; Jawaid Younus; Sara Kuruvilla; Stewart Gaede; Grace Parraga; Brian P Yaremko
Journal:  BMC Cancer       Date:  2014-12-11       Impact factor: 4.430

9.  V/Q SPECT for the Assessment of Regional Lung Function: Generation of Normal Mean and Standard Deviation 3-D Maps.

Authors:  David Bourhis; Philippe Robin; Marine Essayan; Ronan Abgral; Solène Querellou; Cécile Tromeur; Pierre-Yves Salaun; Pierre-Yves Le Roux
Journal:  Front Med (Lausanne)       Date:  2020-04-28
  9 in total

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