Literature DB >> 1899326

Comparison of bacteriostatic and bactericidal activity of isoniazid and ethionamide against Mycobacterium avium and Mycobacterium tuberculosis.

L B Heifets1, P J Lindholm-Levy, M Flory.   

Abstract

Minimal inhibitory and bactericidal concentrations (MIC and MBC) of isoniazid and ethionamide were determined in 7H12 broth in experiments with 68 Mycobacterium avium strains and 14 wild drug-susceptible M. tuberculosis strains. MICs of isoniazid for M. tuberculosis were from 0.025 to 0.05 microgram/ml, and for M. avium from 0.6 to greater than 10.0 micrograms/ml. MICs of ethionamide for M. tuberculosis were from 0.3 to 1.25 micrograms/ml, and 42.7% of M. avium strains were within the same range. Isoniazid and ethionamide were highly bactericidal against M. tuberculosis, but they had very low bactericidal activity against M. avium.

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Year:  1991        PMID： 1899326     DOI： 10.1164/ajrccm/143.2.268

Source DB:  PubMed          Journal:  Am Rev Respir Dis        ISSN： 0003-0805


  12 in total

1.  Multicenter laboratory validation of susceptibility testing of Mycobacterium tuberculosis against classical second-line and newer antimicrobial drugs by using the radiometric BACTEC 460 technique and the proportion method with solid media.

Authors:  G E Pfyffer; D A Bonato; A Ebrahimzadeh; W Gross; J Hotaling; J Kornblum; A Laszlo; G Roberts; M Salfinger; F Wittwer; S Siddiqi
Journal:  J Clin Microbiol       Date:  1999-10       Impact factor: 5.948

2.  Effects of AIDS and gender on steady-state plasma and intrapulmonary ethionamide concentrations.

Authors:  J E Conte; J A Golden; M McQuitty; J Kipps; E T Lin; E Zurlinden
Journal:  Antimicrob Agents Chemother       Date:  2000-05       Impact factor: 5.191

3.  Pharmacokinetics of isoniazid, rifampin, and pyrazinamide in children younger than two years of age with tuberculosis: evidence for implementation of revised World Health Organization recommendations.

Authors:  S Thee; J A Seddon; P R Donald; H I Seifart; C J Werely; A C Hesseling; B Rosenkranz; S Roll; K Magdorf; H S Schaaf
Journal:  Antimicrob Agents Chemother       Date:  2011-10-03       Impact factor: 5.191

4.  Pharmacokinetics of ethionamide in children.

Authors:  S Thee; H I Seifart; B Rosenkranz; A C Hesseling; K Magdorf; P R Donald; H S Schaaf
Journal:  Antimicrob Agents Chemother       Date:  2011-07-25       Impact factor: 5.191

5.  SQ109 targets MmpL3, a membrane transporter of trehalose monomycolate involved in mycolic acid donation to the cell wall core of Mycobacterium tuberculosis.

Authors:  Kapil Tahlan; Regina Wilson; David B Kastrinsky; Kriti Arora; Vinod Nair; Elizabeth Fischer; S Whitney Barnes; John R Walker; David Alland; Clifton E Barry; Helena I Boshoff
Journal:  Antimicrob Agents Chemother       Date:  2012-01-17       Impact factor: 5.191

6.  Rapid broth macrodilution method for determination of MICs for Mycobacterium avium isolates.

Authors:  S H Siddiqi; L B Heifets; M H Cynamon; N M Hooper; A Laszlo; J P Libonati; P J Lindholm-Levy; N Pearson
Journal:  J Clin Microbiol       Date:  1993-09       Impact factor: 5.948

7.  Resazurin microtiter assay plate testing of Mycobacterium tuberculosis susceptibilities to second-line drugs: rapid, simple, and inexpensive method.

Authors:  Anandi Martin; Mirtha Camacho; Françoise Portaels; Juan Carlos Palomino
Journal:  Antimicrob Agents Chemother       Date:  2003-11       Impact factor: 5.191

8.  Rapid detection of Mycobacterium tuberculosis resistance to second-line drugs by use of the manual mycobacterium growth indicator tube system.

Authors:  Anandi Martin; Andrea von Groll; Krista Fissette; Juan Carlos Palomino; Francis Varaine; Françoise Portaels
Journal:  J Clin Microbiol       Date:  2008-10-22       Impact factor: 5.948

9.  In vitro and ex vivo activities of antimicrobial agents used in combination with clarithromycin, with or without amikacin, against Mycobacterium avium.

Authors:  L Fattorini; B Li; C Piersimoni; E Tortoli; Y Xiao; C Santoro; M L Ricci; G Orefici
Journal:  Antimicrob Agents Chemother       Date:  1995-03       Impact factor: 5.191

10.  Assessing whether isoniazid is essential during the first 14 days of tuberculosis therapy: a phase 2a, open-label, randomised controlled trial.

Authors:  Andreas Diacon; Sachiko Miyahara; Rodney Dawson; Xin Sun; Evelyn Hogg; Kathleen Donahue; Michael Urbanowski; Veronique De Jager; Courtney V Fletcher; Richard Hafner; Susan Swindells; William Bishai
Journal:  Lancet Microbe       Date:  2020-06-08
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