Literature DB >> 18990470

2-Azetidinone derivatives: design, synthesis and evaluation of cholesterol absorption inhibitors.

Yubin Wang1, Huibin Zhang, Wenlong Huang, Jing Kong, Jinpei Zhou, Beibei Zhang.   

Abstract

Fourteen new derivatives of the 2-azetidinone cholesterol absorption inhibitors have been synthesized, and three of them were enantiomerically pure. All the new compounds were evaluated for their activity to inhibit cholesterol absorption in rats, and most of them showed comparable effects in lowering the levels of total cholesterol in the serum.

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Year:  2008        PMID： 18990470     DOI： 10.1016/j.ejmech.2008.09.033

Source DB:  PubMed          Journal:  Eur J Med Chem        ISSN： 0223-5234            Impact factor:   6.514


  6 in total

1.  Synthesis and Biological Evaluation of Ezetimibe Analogs as Possible Cholesterol Absorption Inhibitors.

Authors:  Yubin Wang; Wenlong Huang; Huibin Zhang; Jinpei Zhou
Journal:  Lett Drug Des Discov       Date:  2011-07       Impact factor: 1.150

2.  N-(4-Fluoro-phen-yl)-2,2-dimethyl-propan-amide.

Authors:  Zheng Fang; Feng Zhang; Bao-Hua Zou; Kai Guo
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2012-05-16

3.  Synthesis and evaluation of novel amide amino-β-lactam derivatives as cholesterol absorption inhibitors.

Authors:  Tonko Dražić; Vinay Sachdev; Christina Leopold; Jay V Patankar; Martina Malnar; Silva Hećimović; Sanja Levak-Frank; Ivan Habuš; Dagmar Kratky
Journal:  Bioorg Med Chem       Date:  2015-03-31       Impact factor: 3.641

Review 4.  A Review on Recent Advances in Nitrogen-Containing Molecules and Their Biological Applications.

Authors:  Nagaraju Kerru; Lalitha Gummidi; Suresh Maddila; Kranthi Kumar Gangu; Sreekantha B Jonnalagadda
Journal:  Molecules       Date:  2020-04-20       Impact factor: 4.411

5.  N-(5-Chloro-2-nitro-phen-yl)-2,2-di-methyl-propanamide.

Authors:  Feng Zhang; Zheng Fang; Bao-Hua Zou; Guo Kai
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2012-08-25

6.  N-[4-Chloro-3-(trifluoro-meth-yl)phen-yl]-2,2-dimethyl-propanamide.

Authors:  Yu Zhou; Lili Ren; Yongyu Lu; Feng Zhang; Guoguang Chen
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2012-07-25
  6 in total

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