Literature DB >> 18989953

In pursuit of natural product leads: synthesis and biological evaluation of 2-[3-hydroxy-2-[(3-hydroxypyridine-2-carbonyl)amino]phenyl]benzoxazole-4-carboxylic acid (A-33853) and its analogues: discovery of N-(2-benzoxazol-2-ylphenyl)benzamides as novel antileishmanial chemotypes.

Suresh K Tipparaju1, Sipak Joyasawal, Marco Pieroni, Marcel Kaiser, Reto Brun, Alan P Kozikowski.   

Abstract

The first synthesis and biological evaluation of antibiotic 31 (A-33853) and its analogues are reported. Initial screening for inhibition of L. donovani, T. b. rhodesiense, T. cruzi, and P. falciparum cultures followed by determination of IC(50) in L. donovani and cytotoxicity on L6 cells revealed 31 to be 3-fold more active than miltefosine, a known antileishmanial drug. Compounds 14, 15, and 25 selectively inhibited L. donovani at nanomolar concentrations and showed much lower cytotoxicity.

Entities:  

Mesh：

Substances：

Year:  2008        PMID： 18989953     DOI： 10.1021/jm801241n

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  9 in total

Review 1.  Recent developments in drug discovery for leishmaniasis and human African trypanosomiasis.

Authors:  Advait S Nagle; Shilpi Khare; Arun Babu Kumar; Frantisek Supek; Andriy Buchynskyy; Casey J N Mathison; Naveen Kumar Chennamaneni; Nagendar Pendem; Frederick S Buckner; Michael H Gelb; Valentina Molteni
Journal:  Chem Rev       Date:  2014-11-03       Impact factor: 60.622

2.  Sulfonamido-2-arylbenzoxazole GroEL/ES Inhibitors as Potent Antibacterials against Methicillin-Resistant Staphylococcus aureus (MRSA).

Authors:  Sanofar Abdeen; Trent Kunkle; Nilshad Salim; Anne-Marie Ray; Najiba Mammadova; Corey Summers; Mckayla Stevens; Andrew J Ambrose; Yangshin Park; Peter G Schultz; Arthur L Horwich; Quyen Q Hoang; Eli Chapman; Steven M Johnson
Journal:  J Med Chem       Date:  2018-08-14       Impact factor: 7.446

3.  Natural product leads for drug discovery: isolation, synthesis and biological evaluation of 6-cyano-5-methoxyindolo[2,3-a]carbazole based ligands as antibacterial agents.

Authors:  Songpo Guo; Suresh K Tipparaju; Scott D Pegan; Baojie Wan; Shunyan Mo; Jimmy Orjala; Andrew D Mesecar; Scott G Franzblau; Alan P Kozikowski
Journal:  Bioorg Med Chem       Date:  2009-09-04       Impact factor: 3.641

4.  Biosynthesis, Mechanism of Action, and Inhibition of the Enterotoxin Tilimycin Produced by the Opportunistic Pathogen Klebsiella oxytoca.

Authors:  Evan M Alexander; Dale F Kreitler; Valeria Guidolin; Alexander K Hurben; Eric Drake; Peter W Villalta; Silvia Balbo; Andrew M Gulick; Courtney C Aldrich
Journal:  ACS Infect Dis       Date:  2020-06-24       Impact factor: 5.084

Review 5.  Streptomyces: host for refactoring of diverse bioactive secondary metabolites.

Authors:  Vivek Sharma; Randhir Kaur; Richa Salwan
Journal:  3 Biotech       Date:  2021-06-16       Impact factor: 2.893

6.  Exploring the biocombinatorial potential of benzoxazoles: generation of novel caboxamycin derivatives.

Authors:  Armando A Losada; Carmen Méndez; José A Salas; Carlos Olano
Journal:  Microb Cell Fact       Date:  2017-05-25       Impact factor: 5.328

7.  Dissecting The role of Plasmodium metacaspase-2 in malaria gametogenesis and sporogony.

Authors:  Vandana Kumari; Kona Madhavinadha Prasad; Inderjeet Kalia; Gagandeep Sindhu; Rajnikant Dixit; Diwan S Rawat; O P Singh; Agam P Singh; Kailash C Pandey
Journal:  Emerg Microbes Infect       Date:  2022-12       Impact factor: 7.163

8.  High-Throughput Screening Platform To Identify Inhibitors of Protein Synthesis with Potential for the Treatment of Malaria.

Authors:  Fabio Tamaki; Fabio Fisher; Rachel Milne; Fernando Sánchez-Román Terán; Natalie Wiedemar; Karolina Wrobel; Darren Edwards; Hella Baumann; Ian H Gilbert; Beatriz Baragana; Jake Baum; Susan Wyllie
Journal:  Antimicrob Agents Chemother       Date:  2022-06-01       Impact factor: 5.938

9.  Alternative Benzoxazole Assembly Discovered in Anaerobic Bacteria Provides Access to Privileged Heterocyclic Scaffold.

Authors:  Therese Horch; Evelyn M Molloy; Florian Bredy; Veit G Haensch; Kirstin Scherlach; Kyle L Dunbar; Jonathan Franke; Christian Hertweck
Journal:  Angew Chem Int Ed Engl       Date:  2022-06-28       Impact factor: 16.823
  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.