| Literature DB >> 18989718 |
Naohiro Gotoh1, Hiroyuki Watanabe, Tomiko Oka, Daisuke Mashimo, Noriko Noguchi, Kazuhiko Hata, Shun Wada.
Abstract
The biologic availability of two kinds of tocomonoenols, marine-derived tocopherol (MDT) and alpha-tocomonoenol, was investigated in ICR mice. Vitamin E-deficient ICR mice were fed MDT and alpha-tocomonoenol together with alpha-tocopherol, beta-tocopherol, gamma-tocopherol, and delta-tocopherol, and storage in liver, spleen, lung, and brain was quantified using reverse-phase high-performance liquid chromatography. The vitamin E relative biologic availability (VE-RBA) in liver was 100 for alpha-tocopherol, 26 +/- 3 for beta-tocopherol, 4 +/- 2 for gamma-tocopherol, not detected for delta-tocopherol, 49 +/- 6 for MDT, and 30 +/- 7 for alpha-tocomonoenol. The VE-RBA in brain was 100 for alpha-tocopherol, 5 +/- 2 for beta-tocopherol, not detected for gamma-tocopherol and delta-tocopherol, 8 +/- 1 for MDT, and 4 +/- 1 for alpha-tocomonoenol. Tocopherols and tocomonoenols did not accumulate in the spleen or lung. MDT and alpha-tocomonoenol had high VE-RBA values. The VE-RBA value for MDT was much higher than that for beta-tocopherol.Entities:
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Year: 2008 PMID： 18989718 DOI： 10.1007/s11745-008-3257-3
Source DB: PubMed Journal: Lipids ISSN： 0024-4201 Impact factor: 1.880