BACKGROUND: Fish consumption has been shown to be inversely associated with CHD, which may be due to n-3 fatty acids. The n-3 fatty acids, EPA and DHA, are naturally found only in marine sources. Dietary intakes of methylmercury from certain fish have been hypothesized to increase the risk of CHD. OBJECTIVE: To investigate the relationship between 30 d fish frequency consumption (assessed by FFQ), total blood Hg concentrations and risk markers of CHD in women aged 16-49 years participating in the National Health and Nutrition Examination Survey 1999-2002. DESIGN: Multiple linear regression analyses were used to test (i) the relationships between 30 d fish frequency consumption and five CHD risk markers, i.e. HDL cholesterol (HDL-C), LDL cholesterol, total cholesterol, TAG and C-reactive protein (CRP); and (ii) if total blood Hg attenuated any associations between fish consumption and CHD risk markers in non-pregnant, non-diabetic females aged 16-49 years. RESULTS: Total 30 d fish frequency consumption was negatively associated with CRP (b = -0.10, 95 % CI -0.19, -0.02, P = 0.015) and positively associated with HDL-C (b = 1.40, 95 % CI 0.31, 2.50, P = 0.014). Adjustment for other risk factors did not significantly attenuate the associations. Despite the collinearity between fish and Hg, there is a protective association between fish intake and CHD risk factors. CONCLUSIONS: The levels of DHA + EPA and other nutrients in fish may be adequate to offset the hypothesized risks of heart disease related to ingesting Hg from fish.
BACKGROUND: Fish consumption has been shown to be inversely associated with CHD, which may be due to n-3 fatty acids. The n-3 fatty acids, EPA and DHA, are naturally found only in marine sources. Dietary intakes of methylmercury from certain fish have been hypothesized to increase the risk of CHD. OBJECTIVE: To investigate the relationship between 30 d fish frequency consumption (assessed by FFQ), total blood Hg concentrations and risk markers of CHD in women aged 16-49 years participating in the National Health and Nutrition Examination Survey 1999-2002. DESIGN: Multiple linear regression analyses were used to test (i) the relationships between 30 d fish frequency consumption and five CHD risk markers, i.e. HDL cholesterol (HDL-C), LDL cholesterol, total cholesterol, TAG and C-reactive protein (CRP); and (ii) if total blood Hg attenuated any associations between fish consumption and CHD risk markers in non-pregnant, non-diabetic females aged 16-49 years. RESULTS: Total 30 d fish frequency consumption was negatively associated with CRP (b = -0.10, 95 % CI -0.19, -0.02, P = 0.015) and positively associated with HDL-C (b = 1.40, 95 % CI 0.31, 2.50, P = 0.014). Adjustment for other risk factors did not significantly attenuate the associations. Despite the collinearity between fish and Hg, there is a protective association between fish intake and CHD risk factors. CONCLUSIONS: The levels of DHA + EPA and other nutrients in fish may be adequate to offset the hypothesized risks of heart disease related to ingesting Hg from fish.
Authors: Brooks B Gump; James A MacKenzie; Amy K Dumas; Christopher D Palmer; Patrick J Parsons; Zaneer M Segu; Yehia S Mechref; Kestutis G Bendinskas Journal: Environ Res Date: 2011-10-24 Impact factor: 6.498
Authors: V D F de Mello; U Schwab; M Kolehmainen; W Koenig; M Siloaho; K Poutanen; H Mykkänen; M Uusitupa Journal: Diabetologia Date: 2011-08-26 Impact factor: 10.122
Authors: Mary Turyk; Giamila Fantuzzi; Victoria Persky; Sally Freels; Anissa Lambertino; Maria Pini; Davina H Rhodes; Henry A Anderson Journal: Environ Res Date: 2015-04-22 Impact factor: 6.498
Authors: Ida Heir Hovland; Ingrid Sande Leikanger; Oddbjørg Stokkeland; Kaia Hevrøy Waage; Svein A Mjøs; Karl A Brokstad; Adrian McCann; Per Magne Ueland; Rasa Slizyte; Ana Carvajal; Gunnar Mellgren; Tore Remman; Ingmar Høgøy; Oddrun A Gudbrandsen Journal: Eur J Nutr Date: 2019-04-10 Impact factor: 5.614