Gerhard Höfle1, Herbert Irschik. 1. Helmholtz Centre for Infection Research (previously GBF, Gesellschaft für Biotechnologische Forschung), Inhoffenstrasse 7, 38124 Braunschweig, Germany. gho@helmholtz-hzi.de
Abstract
The isolation of aurachin P (2) from Stigmatella erecta strain Pd e32 is described. Spectroscopic data, in particular NMR data, indicate it is 1'-hydroxyaurachin A with a 1'R,2'S,3'R relative configuration. In addition, a further compound, 5-nitroresorcinol (4a), was isolated and identified as a novel natural product. Feeding of (13)C- and (15)N-labeled precursors indicated this was synthesized solely from glucose and ammonia. To account for the labeling pattern, phloroglucinol (8) is postulated as an intermediate branching off from 3-dehydroquinate (7) in the shikimate pathway.
The isolation of aurachin P (2) from n class="Species">Stigmatella erecta strain Pd e32 is described. Spectroscopic data, in particular NMR data, indicate it is 1'-hydroxyaurachin A with a 1'R,2'S,3'R relative configuration. In addition, a further compound, 5-nitroresorcinol (4a), was isolated and identified as a novel natural product. Feeding of (13)C- and (15)N-labeled precursors indicated this was synthesized solely from glucose and ammonia. To account for the labeling pattern, phloroglucinol (8) is postulated as an intermediate branching off from 3-dehydroquinate (7) in the shikimate pathway.
Authors: Angela Sester; Katrin Stüer-Patowsky; Wolf Hiller; Florian Kloss; Stephan Lütz; Markus Nett Journal: Chembiochem Date: 2020-05-05 Impact factor: 3.164