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Literature DB >> 189859

Hydrogen peroxide production and killing of Staphylococcus aureus by human polymorphonuclear leukocytes.

Abstract

The effects of bacterial neuraminidase on production of hydrogen peroxide (H2O2) and killing of Staphylococcus aureus by human polymorphonuclear leukocytes (PMN) were studied. The concentration of H2O2 was measured by the disappearance of scopoletin fluorescence in the presence of horseradish peroxidase. The results indicated that desialylation of human PMN inhibited the stimulation of H2O2 production during phagocytosis. It also markedly impaired the killing of S. aureus. Impaired killing of S. aureus by desialylated PMN was due to impaired intracellular killing rather than defective phagocytosis.

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Year: 1977 PMID： 189859

Source DB: PubMed Journal: Blood ISSN： 0006-4971 Impact factor: 22.113

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Cited

14 in total

1. Superoxide generation by digitonin-stimulated guinea pig granulocytes. A basis for a continuous assay for monitoring superoxide production and for the study of the activation of the generating system.

Authors: H J Cohen; M E Chovaniec
Journal: J Clin Invest Date: 1978-04 Impact factor: 14.808

2. Differences in the ingestion mechanisms of IgG and C3b particles in phagocytosis by neutrophils.

Authors: J Hed; O Stendahl
Journal: Immunology Date: 1982-04 Impact factor: 7.397

3. Deleterious effects of endotoxin on cultured endothelial cells: an in vitro model of vascular injury.

Authors: O Yamada; C F Moldow; T Sacks; P R Craddock; M A Boogaerts; H S Jacob
Journal: Inflammation Date: 1981-06 Impact factor: 4.092

4. Kinetic studies of neutrophil phagocytosis. V. studies on the co-operation between the Fc and C3b receptors.

Authors: L Håkansson; P Venge
Journal: Immunology Date: 1982-12 Impact factor: 7.397

5. Role of granulocyte oxygen products in damage of Schistosoma mansoni eggs in vitro.

Authors: J W Kazura; P de Brito; J Rabbege; M Aikawa
Journal: J Clin Invest Date: 1985-04 Impact factor: 14.808

6. Role of cell-generated hydrogen peroxide in granulocyte-mediated killing of schistosomula of Schistosoma mansoni in vitro.

Authors: J W Kazura; M M Fanning; J L Blumer; A A Mahmoud
Journal: J Clin Invest Date: 1981-01 Impact factor: 14.808

Hydrogen peroxide production and killing of Staphylococcus aureus by human polymorphonuclear leukocytes.

1. Superoxide generation by digitonin-stimulated guinea pig granulocytes. A basis for a continuous assay for monitoring superoxide production and for the study of the activation of the generating system.

2. Differences in the ingestion mechanisms of IgG and C3b particles in phagocytosis by neutrophils.

3. Deleterious effects of endotoxin on cultured endothelial cells: an in vitro model of vascular injury.

4. Kinetic studies of neutrophil phagocytosis. V. studies on the co-operation between the Fc and C3b receptors.

5. Role of granulocyte oxygen products in damage of Schistosoma mansoni eggs in vitro.

6. Role of cell-generated hydrogen peroxide in granulocyte-mediated killing of schistosomula of Schistosoma mansoni in vitro.

7. Effect of deuterium oxide on neutrophil oxidative metabolism, phagocytosis, and lysosomal enzyme release.

8. Oxidant-mediated damage of Leishmania donovani promastigotes.

9. Susceptibility of Blastomyces dermatitidis strains to products of oxidative metabolism.

10. Oxidation of methionine by human polymorphonuclear leukocytes.