Literature DB >> 6268539

Deleterious effects of endotoxin on cultured endothelial cells: an in vitro model of vascular injury.

O Yamada, C F Moldow, T Sacks, P R Craddock, M A Boogaerts, H S Jacob.   

Abstract

The effects of endotoxin-triggered granulocytes on the viability of endothelial cells in vitro was investigated. Endotoxin or its lipid A component caused granulocytes to adhere to and significantly damage cultured endothelial cells. Fresh serum is not necessary but does amplify both adherence and endothelial injury. Much of the endothelial injury was inhibited by free-radical scavengers or by blocking granulocyte adhesion to endothelial cells and appears to result from free radical production by the stimulated granulocyte. Studies in this model suggest a pathogenic role for the endotoxin-triggered granulocyte in the Shwartzman reaction and perhaps related clinical disorders.

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Year:  1981        PMID： 6268539     DOI： 10.1007/bf00914201

Source DB:  PubMed          Journal:  Inflammation        ISSN： 0360-3997            Impact factor:   4.092


  31 in total

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Journal:  Proc Natl Acad Sci U S A       Date:  1967-03       Impact factor: 11.205

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Journal:  Science       Date:  1970-11-27       Impact factor: 47.728

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Journal:  J Immunol       Date:  1975-07       Impact factor: 5.422

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Journal:  Thromb Diath Haemorrh       Date:  1966-05-15

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Authors:  F R Rickles; P D Rick
Journal:  J Clin Invest       Date:  1977-06       Impact factor: 14.808

7.  Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria.

Authors:  E A Jaffe; R L Nachman; C G Becker; C R Minick
Journal:  J Clin Invest       Date:  1973-11       Impact factor: 14.808

8.  Corticosteroids inhibit complement-induced granulocyte aggregation. A possible mechanism for their efficacy in shock states.

Authors:  D E Hammerschmidt; J G White; P R Craddock; H S Jacob
Journal:  J Clin Invest       Date:  1979-04       Impact factor: 14.808

9.  Studies on the mechanism of the Shwartzman-phenomenon; evidence for the participation of polymorphonuclear leucocytes in the phenomenon.

Authors:  C A STETSON; R A GOOD
Journal:  J Exp Med       Date:  1951-01       Impact factor: 14.307

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Authors:  R A GOOD; L THOMAS
Journal:  J Exp Med       Date:  1953-06       Impact factor: 14.307
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  19 in total

1.  Adhesion of polymorphonuclear leukocytes to endothelium enhances the efficiency of detoxification of oxygen-free radicals.

Authors:  R L Hoover; J M Robinson; M J Karnovsky
Journal:  Am J Pathol       Date:  1987-02       Impact factor: 4.307

2.  Enhancement of granulocyte-endothelial cell adherence and granulocyte-induced cytotoxicity by platelet release products.

Authors:  M A Boogaerts; O Yamada; H S Jacob; C F Moldow
Journal:  Proc Natl Acad Sci U S A       Date:  1982-11       Impact factor: 11.205

3.  Poor outcome from peritonitis is caused by disease acuity and organ failure, not recurrent peritoneal infection.

Authors:  D J Wickel; W G Cheadle; M A Mercer-Jones; R N Garrison
Journal:  Ann Surg       Date:  1997-06       Impact factor: 12.969

4.  Endotoxin enhances tissue factor and suppresses thrombomodulin expression of human vascular endothelium in vitro.

Authors:  K L Moore; S P Andreoli; N L Esmon; C T Esmon; N U Bang
Journal:  J Clin Invest       Date:  1987-01       Impact factor: 14.808

5.  Kinetics of thrombomodulin release and endothelial cell injury by neutrophil-derived proteases and oxygen radicals.

Authors:  Michael W J Boehme; Peter Galle; Wolfgang Stremmel
Journal:  Immunology       Date:  2002-11       Impact factor: 7.397

6.  Adult respiratory distress syndrome in neutropenic leukemia patients.

Authors:  J F Vansteenkiste; M A Boogaerts
Journal:  Blut       Date:  1989-06

7.  Neutrophil-endothelial cell interaction. Evidence for and mechanisms of the self-protection of bovine microvascular endothelial cells from hydrogen peroxide-induced oxidative stress.

Authors:  A Dobrina; P Patriarca
Journal:  J Clin Invest       Date:  1986-08       Impact factor: 14.808

8.  Lipopolysaccharide augments HLA-A,B,C molecule expression but inhibits interferon-gamma-induced HLA-DR molecule expression on cultured human endothelial cells.

Authors:  A Otsuka; T Hanafusa; N Kono; S Tarui
Journal:  Immunology       Date:  1991-08       Impact factor: 7.397

9.  Stimulation of human polymorphonuclear leukocyte oxidative metabolism by type 1 pili from Escherichia coli.

Authors:  M B Goetz; F J Silverblatt
Journal:  Infect Immun       Date:  1987-03       Impact factor: 3.441

10.  Neutrophil-mediated injury to endothelial cells. Enhancement by endotoxin and essential role of neutrophil elastase.

Authors:  L A Smedly; M G Tonnesen; R A Sandhaus; C Haslett; L A Guthrie; R B Johnston; P M Henson; G S Worthen
Journal:  J Clin Invest       Date:  1986-04       Impact factor: 14.808
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