Literature DB >> 18985293

From genes to psychoses and back: the role of the 5HT2alpha-receptor and prepulse inhibition in schizophrenia.

Wolfgang Maier1, Rainald Mössner, Boris B Quednow, Michael Wagner, René Hurlemann.   

Abstract

Decomposition of schizophrenia into neurobiological vulnerability traits is necessary to understand the complex genetic underpinnings of this phenomenologically defined disorder. This issue is discussed with a focus on prepulse inhibition (PPI) as a neurobiological phenotype and the 5HT2a-receptor as a candidate gene. A series of recent studies illuminates that PPI and 5HT2a-receptors present as vulnerability markers for schizophrenia; a functional sequence variant in the 5HT2a-gene is contributing to this relationship and might consequently contribute to the genetic predisposition to schizophrenia with a very small risk increase.

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Year:  2008        PMID： 18985293     DOI： 10.1007/s00406-008-5011-5

Source DB:  PubMed          Journal:  Eur Arch Psychiatry Clin Neurosci        ISSN： 0940-1334            Impact factor:   5.270


  20 in total

1.  Prepulse inhibition of the startle response in men with schizophrenia: effects of age of onset of illness, symptoms, and medication.

Authors:  V Kumari; W Soni; V M Mathew; T Sharma
Journal:  Arch Gen Psychiatry       Date:  2000-06

2.  Identification of loci associated with schizophrenia by genome-wide association and follow-up.

Authors:  Michael C O'Donovan; Nicholas Craddock; Nadine Norton; Hywel Williams; Timothy Peirce; Valentina Moskvina; Ivan Nikolov; Marian Hamshere; Liam Carroll; Lyudmila Georgieva; Sarah Dwyer; Peter Holmans; Jonathan L Marchini; Chris C A Spencer; Bryan Howie; Hin-Tak Leung; Annette M Hartmann; Hans-Jürgen Möller; Derek W Morris; Yongyong Shi; GuoYin Feng; Per Hoffmann; Peter Propping; Catalina Vasilescu; Wolfgang Maier; Marcella Rietschel; Stanley Zammit; Johannes Schumacher; Emma M Quinn; Thomas G Schulze; Nigel M Williams; Ina Giegling; Nakao Iwata; Masashi Ikeda; Ariel Darvasi; Sagiv Shifman; Lin He; Jubao Duan; Alan R Sanders; Douglas F Levinson; Pablo V Gejman; Sven Cichon; Markus M Nöthen; Michael Gill; Aiden Corvin; Dan Rujescu; George Kirov; Michael J Owen; Nancy G Buccola; Bryan J Mowry; Robert Freedman; Farooq Amin; Donald W Black; Jeremy M Silverman; William F Byerley; C Robert Cloninger
Journal:  Nat Genet       Date:  2008-09       Impact factor: 38.330

Review 3.  Using an animal model of deficient sensorimotor gating to study the pathophysiology and new treatments of schizophrenia.

Authors:  N R Swerdlow; M A Geyer
Journal:  Schizophr Bull       Date:  1998       Impact factor: 9.306

Review 4.  Animal models of deficient sensorimotor gating: what we know, what we think we know, and what we hope to know soon.

Authors:  N R Swerdlow; D L Braff; M A Geyer
Journal:  Behav Pharmacol       Date:  2000-06       Impact factor: 2.293

5.  Supportive evidence for the association between the T102C 5-HTR2A gene polymorphism and schizophrenia: a large-scale case-control and family-based study.

Authors:  V E Golimbet; O M Lavrushina; V G Kaleda; L I Abramova; T V Lezheiko
Journal:  Eur Psychiatry       Date:  2007-01-19       Impact factor: 5.361

6.  The effects of the preferential 5-HT2A agonist psilocybin on prepulse inhibition of startle in healthy human volunteers depend on interstimulus interval.

Authors:  Franz X Vollenweider; Philipp A Csomor; Bernhard Knappe; Mark A Geyer; Boris B Quednow
Journal:  Neuropsychopharmacology       Date:  2007-02-14       Impact factor: 7.853

7.  Sensorimotor gating of schizophrenia patients depends on Catechol O-methyltransferase Val158Met polymorphism.

Authors:  Boris B Quednow; Michael Wagner; Rainald Mössner; Wolfgang Maier; Kai-Uwe Kühn
Journal:  Schizophr Bull       Date:  2008-07-17       Impact factor: 9.306

8.  The -1438A/G polymorphism in the 5-hydroxytryptamine type 2A receptor gene affects promoter activity.

Authors:  Michael J Parsons; Ursula M D'Souza; Maria-Jesus Arranz; Robert W Kerwin; Andrew J Makoff
Journal:  Biol Psychiatry       Date:  2004-09-15       Impact factor: 13.382

Review 9.  HTR2A gene variants and psychiatric disorders: a review of current literature and selection of SNPs for future studies.

Authors:  Alessandro Serretti; Antonio Drago; Diana De Ronchi
Journal:  Curr Med Chem       Date:  2007       Impact factor: 4.530

10.  Genetic influences on prepulse inhibition of startle reflex in humans.

Authors:  Andrey P Anokhin; Andrew C Heath; Erin Myers; Angela Ralano; Suzanne Wood
Journal:  Neurosci Lett       Date:  2003-12-15       Impact factor: 3.046
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  9 in total

Review 1.  [Progress in locating the genetic causes of schizophrenia].

Authors:  R Mössner; W Maier; D Rujescu
Journal:  Nervenarzt       Date:  2009-01       Impact factor: 1.214

2.  Mutual independence of 5-HT(2) and α1 noradrenergic receptors in mediating deficits in sensorimotor gating.

Authors:  Sarah K Baisley; Katherine L Fallace; Abha K Rajbhandari; Vaishali P Bakshi
Journal:  Psychopharmacology (Berl)       Date:  2011-09-23       Impact factor: 4.530

3.  No association between prepulse inhibition of the startle reflex and neuropsychological deficit in chronic schizophrenia.

Authors:  Vicente Molina; Benjamín Cortés; Javier Pérez; Carmen Martín; Rocío Villa; Dolores E López; Consuelo Sancho
Journal:  Eur Arch Psychiatry Clin Neurosci       Date:  2010-01-29       Impact factor: 5.270

Review 4.  Epigenetics and biomarkers in the staging of neuropsychiatric disorders.

Authors:  Trevor Archer; Richard J Beninger; Tomas Palomo; Richard M Kostrzewa
Journal:  Neurotox Res       Date:  2010-03-17       Impact factor: 3.911

Review 5.  Treatment implications of the schizophrenia prodrome.

Authors:  Tejal Kaur; Kristin S Cadenhead
Journal:  Curr Top Behav Neurosci       Date:  2010

6.  Sleep, hypothalamus, and stigma.

Authors:  Peter Falkai; Hans-Jürgen Möller
Journal:  Eur Arch Psychiatry Clin Neurosci       Date:  2010-12       Impact factor: 5.270

7.  Prenatal Cocaine Disrupts Serotonin Signaling-Dependent Behaviors: Implications for Sex Differences, Early Stress and Prenatal SSRI Exposure.

Authors:  Sarah K Williams; Jean M Lauder; Josephine M Johns
Journal:  Curr Neuropharmacol       Date:  2011-09       Impact factor: 7.363

8.  State-Dependent Modulation of Visual Evoked Potentials in a Rodent Genetic Model of Electroencephalographic Instability.

Authors:  Janne Grønli; Michelle A Schmidt; Jonathan P Wisor
Journal:  Front Syst Neurosci       Date:  2018-08-15

9.  D-amphetamine and antipsychotic drug effects on latent inhibition in mice lacking dopamine D2 receptors.

Authors:  C Bay-Richter; M J O'Callaghan; N Mathur; C M P O'Tuathaigh; D M Heery; K C F Fone; J L Waddington; P M Moran
Journal:  Neuropsychopharmacology       Date:  2013-02-19       Impact factor: 7.853
  9 in total

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