Literature DB >> 19132332

[Progress in locating the genetic causes of schizophrenia].

R Mössner1, W Maier, D Rujescu.   

Abstract

Elucidation of the pathogenesis of schizophrenia is progressing rapidly. The importance of the glutamatergic system and the glutamate receptor GRM3 were shown in both genetic and pharmacological studies of the new drug LY2140023. The zinc finger domain-containing gene ZNF804A could be identified as a new schizophrenia susceptibility gene, while large copy number variants at 1q21.1 and 15q13.3 now are seen as monogenic causes of schizophrenia. It is anticipated that the coming years will see further rapid progress in the unraveling of the causes of schizophrenia.

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Year:  2009        PMID： 19132332     DOI： 10.1007/s00115-008-2614-z

Source DB:  PubMed          Journal:  Nervenarzt        ISSN： 0028-2804            Impact factor:   1.214


  15 in total

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Journal:  Therapie       Date:  1953       Impact factor: 2.070

3.  Variation in GRM3 affects cognition, prefrontal glutamate, and risk for schizophrenia.

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4.  Structural variation of chromosomes in autism spectrum disorder.

Authors:  Christian R Marshall; Abdul Noor; John B Vincent; Anath C Lionel; Lars Feuk; Jennifer Skaug; Mary Shago; Rainald Moessner; Dalila Pinto; Yan Ren; Bhooma Thiruvahindrapduram; Andreas Fiebig; Stefan Schreiber; Jan Friedman; Cees E J Ketelaars; Yvonne J Vos; Can Ficicioglu; Susan Kirkpatrick; Rob Nicolson; Leon Sloman; Anne Summers; Clare A Gibbons; Ahmad Teebi; David Chitayat; Rosanna Weksberg; Ann Thompson; Cathy Vardy; Vicki Crosbie; Sandra Luscombe; Rebecca Baatjes; Lonnie Zwaigenbaum; Wendy Roberts; Bridget Fernandez; Peter Szatmari; Stephen W Scherer
Journal:  Am J Hum Genet       Date:  2008-01-17       Impact factor: 11.025

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6.  Global variation in copy number in the human genome.

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Journal:  Nature       Date:  2006-11-23       Impact factor: 49.962

7.  Activation of mGlu2/3 receptors as a new approach to treat schizophrenia: a randomized Phase 2 clinical trial.

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Journal:  Nat Med       Date:  2007-09-02       Impact factor: 53.440

8.  Sensorimotor gating of schizophrenia patients is influenced by 5-HT2A receptor polymorphisms.

Authors:  Boris B Quednow; Kai-Uwe Kühn; Rainald Mössner; Sibylle G Schwab; Anna Schuhmacher; Wolfgang Maier; Michael Wagner
Journal:  Biol Psychiatry       Date:  2008-04-16       Impact factor: 13.382

9.  Sensorimotor gating of schizophrenia patients depends on Catechol O-methyltransferase Val158Met polymorphism.

Authors:  Boris B Quednow; Michael Wagner; Rainald Mössner; Wolfgang Maier; Kai-Uwe Kühn
Journal:  Schizophr Bull       Date:  2008-07-17       Impact factor: 9.306

10.  Large recurrent microdeletions associated with schizophrenia.

Authors:  Hreinn Stefansson; Dan Rujescu; Sven Cichon; Olli P H Pietiläinen; Andres Ingason; Stacy Steinberg; Ragnheidur Fossdal; Engilbert Sigurdsson; Thordur Sigmundsson; Jacobine E Buizer-Voskamp; Thomas Hansen; Klaus D Jakobsen; Pierandrea Muglia; Clyde Francks; Paul M Matthews; Arnaldur Gylfason; Bjarni V Halldorsson; Daniel Gudbjartsson; Thorgeir E Thorgeirsson; Asgeir Sigurdsson; Adalbjorg Jonasdottir; Aslaug Jonasdottir; Asgeir Bjornsson; Sigurborg Mattiasdottir; Thorarinn Blondal; Magnus Haraldsson; Brynja B Magnusdottir; Ina Giegling; Hans-Jürgen Möller; Annette Hartmann; Kevin V Shianna; Dongliang Ge; Anna C Need; Caroline Crombie; Gillian Fraser; Nicholas Walker; Jouko Lonnqvist; Jaana Suvisaari; Annamarie Tuulio-Henriksson; Tiina Paunio; Timi Toulopoulou; Elvira Bramon; Marta Di Forti; Robin Murray; Mirella Ruggeri; Evangelos Vassos; Sarah Tosato; Muriel Walshe; Tao Li; Catalina Vasilescu; Thomas W Mühleisen; August G Wang; Henrik Ullum; Srdjan Djurovic; Ingrid Melle; Jes Olesen; Lambertus A Kiemeney; Barbara Franke; Chiara Sabatti; Nelson B Freimer; Jeffrey R Gulcher; Unnur Thorsteinsdottir; Augustine Kong; Ole A Andreassen; Roel A Ophoff; Alexander Georgi; Marcella Rietschel; Thomas Werge; Hannes Petursson; David B Goldstein; Markus M Nöthen; Leena Peltonen; David A Collier; David St Clair; Kari Stefansson
Journal:  Nature       Date:  2008-09-11       Impact factor: 49.962
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  2 in total

Review 1.  [Deconstructing schizophrenia. Dimensional models or division into subtypes?].

Authors:  M Jäger; K Frasch; F U Lang; T Becker
Journal:  Nervenarzt       Date:  2012-03       Impact factor: 1.214

2.  The schizophrenia risk gene ZNF804A influences the antipsychotic response of positive schizophrenia symptoms.

Authors:  Rainald Mössner; Anna Schuhmacher; Michael Wagner; Leonhard Lennertz; Anja Steinbrecher; Boris B Quednow; Dan Rujescu; Marcella Rietschel; Wolfgang Maier
Journal:  Eur Arch Psychiatry Clin Neurosci       Date:  2011-09-04       Impact factor: 5.270
  2 in total

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