| Literature DB >> 18984150 |
Karlyne M Reilly1, Terry Van Dyke.
Abstract
The tumor microenvironment is known to play an important role in tumorigenesis. In this issue, Yang et al. (2008) demonstrate that mast cells heterozygous for the Nf1 gene promote the growth of neurofibromas in a mouse model of neurofibromatosis and that genetic and pharmacological inhibition of these cells is sufficient to block tumor growth.Entities:
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Year: 2008 PMID： 18984150 PMCID： PMC2693258 DOI： 10.1016/j.cell.2008.10.009
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582