Literature DB >> 18979480

Addressing the PEG mucoadhesivity paradox to engineer nanoparticles that "slip" through the human mucus barrier.

Ying-Ying Wang1, Samuel K Lai, Jung Soo Suk, Amanda Pace, Richard Cone, Justin Hanes.   

Abstract

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Year:  2008        PMID： 18979480      PMCID： PMC2666733          DOI： 10.1002/anie.200803526

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


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5.  Mucoadhesive drug carriers based on complexes of poly(acrylic acid) and PEGylated drugs having hydrolysable PEG-anhydride-drug linkages.

Authors:  B S Lele; A S Hoffman
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Review 6.  Surface modifications and molecular imprinting of polymers in medical and pharmaceutical applications.

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9.  Comparative uptake studies of bioadhesive and non-bioadhesive nanoparticles in human intestinal cell lines and rats: the effect of mucus on particle adsorption and transport.

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6.  Antibiofilm Efficacy of Nitric Oxide-Releasing Alginates against Cystic Fibrosis Bacterial Pathogens.

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Review 7.  Nano-enabled delivery of diverse payloads across complex biological barriers.

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8.  Particulate matter in cigarette smoke increases ciliary axoneme beating through mechanical stimulation.

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9.  The penetration of fresh undiluted sputum expectorated by cystic fibrosis patients by non-adhesive polymer nanoparticles.

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10.  Nanoparticle penetration of human cervicovaginal mucus: the effect of polyvinyl alcohol.

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