Literature DB >> 18978832

DNA damage and ageing: new-age ideas for an age-old problem.

George A Garinis1, Gijsbertus T J van der Horst, Jan Vijg, Jan H J Hoeijmakers.   

Abstract

Loss of genome maintenance may causally contribute to ageing, as exemplified by the premature appearance of multiple symptoms of ageing in a growing family of human syndromes and in mice with genetic defects in genome maintenance pathways. Recent evidence revealed a similarity between such prematurely ageing mutants and long-lived mice harbouring mutations in growth signalling pathways. At first sight this seems paradoxical as they represent both extremes of ageing yet show a similar 'survival' response that is capable of delaying age-related pathology and extending lifespan. Understanding the mechanistic basis of this response and its connection with genome maintenance would open exciting possibilities for counteracting cancer or age-related diseases, and for promoting longevity.

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Year:  2008        PMID： 18978832      PMCID： PMC4351702          DOI： 10.1038/ncb1108-1241

Source DB:  PubMed          Journal:  Nat Cell Biol        ISSN： 1465-7392            Impact factor:   28.824


  60 in total

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9.  DNA damage in normally and prematurely aged mice.

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