Literature DB >> 18977589

Suppression of androgen receptor signaling and prostate specific antigen expression by (-)-epigallocatechin-3-gallate in different progression stages of LNCaP prostate cancer cells.

Chih-Pin Chuu1, Rou-Yu Chen, John M Kokontis, Richard A Hiipakka, Shutsung Liao.   

Abstract

The green tea polyphenol, (-)-epigallocatechin-3-gallate (EGCG), inhibits the development and progression of prostate cancer in TRAMP mice and in men. We examined the effects of EGCG on LNCaP human prostate cancer sublines 104-S, 104-R1 and R1Ad representing different progression stages of prostate cancer. EGCG suppressed cell proliferation, prostate specific antigen (PSA) expression, and AR transcriptional activity in the different LNCaP sublines. Intraperitoneal administration of EGCG also suppressed the growth of relapsing R1Ad tumors and decreased tumor-derived serum PSA. Effects of EGCG on tumor PSA expression have the potential to affect accurate monitoring of patient tumor burden by serum PSA measurements.

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Year:  2008        PMID： 18977589      PMCID： PMC2980538          DOI： 10.1016/j.canlet.2008.10.001

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  29 in total

Review 1.  Green tea: biochemical and biological basis for health benefits.

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2.  Tea polyphenols down-regulate the expression of the androgen receptor in LNCaP prostate cancer cells.

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4.  Inhibition of prostate carcinogenesis in TRAMP mice by oral infusion of green tea polyphenols.

Authors:  S Gupta; K Hastak; N Ahmad; J S Lewin; H Mukhtar
Journal:  Proc Natl Acad Sci U S A       Date:  2001-08-14       Impact factor: 11.205

5.  Modulation of endocrine systems and food intake by green tea epigallocatechin gallate.

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  34 in total

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Review 7.  Plant-Derived Natural Products in Cancer Research: Extraction, Mechanism of Action, and Drug Formulation.

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9.  Ericifolin: a novel antitumor compound from allspice that silences androgen receptor in prostate cancer.

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10.  Caffeic acid phenethyl ester suppresses the proliferation of human prostate cancer cells through inhibition of p70S6K and Akt signaling networks.

Authors:  Chih-Pin Chuu; Hui-Ping Lin; Mark F Ciaccio; John M Kokontis; Ronald J Hause; Richard A Hiipakka; Shutsung Liao; Richard Baker Jones
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