Literature DB >> 18974104

Just say no to ATOH: how HIC1 methylation might predispose medulloblastoma to lineage addiction.

Kimberly J Briggs1, Charles G Eberhart, D Neil Watkins.   

Abstract

Hypermethylated in cancer-1 (HIC1) is a tumor suppressor frequently targeted for promoter hypermethylation in medulloblastoma, an embryonal tumor of the cerebellum. Recently, we showed that HIC1 is a direct transcriptional repressor of ATOH1, a proneural transcription factor required for normal cerebellar development, as well as for medulloblastoma cell viability. Because demethylating agents can induce reexpression of silenced tumor suppressors, restoring HIC1 function may present an attractive therapeutic avenue in medulloblastoma by exploiting an apparent addiction to ATOH1.

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Year:  2008        PMID： 18974104      PMCID： PMC2702666          DOI： 10.1158/0008-5472.CAN-08-1904

Source DB:  PubMed          Journal:  Cancer Res        ISSN： 0008-5472            Impact factor:   12.701


  34 in total

1.  Involvement of multiple chromosome 17p loci in medulloblastoma tumorigenesis.

Authors:  P H Cogen; L Daneshvar; A K Metzger; G Duyk; M S Edwards; V C Sheffield
Journal:  Am J Hum Genet       Date:  1992-03       Impact factor: 11.025

2.  Identification of tumour-specific epigenetic events in medulloblastoma development by hypermethylation profiling.

Authors:  Janet C Lindsey; Meryl E Lusher; Jennifer A Anderton; Simon Bailey; Richard J Gilbertson; Andrew D J Pearson; David W Ellison; Steven C Clifford
Journal:  Carcinogenesis       Date:  2003-12-19       Impact factor: 4.944

3.  REN(KCTD11) is a suppressor of Hedgehog signaling and is deleted in human medulloblastoma.

Authors:  Lucia Di Marcotullio; Elisabetta Ferretti; Enrico De Smaele; Beatrice Argenti; Claudia Mincione; Francesca Zazzeroni; Rita Gallo; Laura Masuelli; Maddalena Napolitano; Marella Maroder; Andrea Modesti; Felice Giangaspero; Isabella Screpanti; Edoardo Alesse; Alberto Gulino
Journal:  Proc Natl Acad Sci U S A       Date:  2004-07-12       Impact factor: 11.205

4.  Epigenetic silencing of the HIC-1 gene in human medulloblastomas.

Authors:  Anke Waha; Andreas Waha; Arend Koch; Birgit Meyer-Puttlitz; Sascha Weggen; Nils Sörensen; Jörg C Tonn; Steffen Albrecht; Cynthia G Goodyer; Frank Berthold; Otmar D Wiestler; Torsten Pietsch
Journal:  J Neuropathol Exp Neurol       Date:  2003-11       Impact factor: 3.685

5.  Medulloblastoma tumorigenesis diverges from cerebellar granule cell differentiation in patched heterozygous mice.

Authors:  John Y H Kim; Aaron L Nelson; Sibel A Algon; Ondrea Graves; Lisa Marie Sturla; Liliana C Goumnerova; David H Rowitch; Rosalind A Segal; Scott L Pomeroy
Journal:  Dev Biol       Date:  2003-11-01       Impact factor: 3.582

6.  Identification of a second G-C-rich promoter conserved in the human, murine and rat tumor suppressor genes HIC1.

Authors:  Sébastien Pinte; Cateline Guérardel; Sophie Deltour-Balerdi; Andrew K Godwin; Dominique Leprince
Journal:  Oncogene       Date:  2004-05-13       Impact factor: 9.867

7.  Nmyc upregulation by sonic hedgehog signaling promotes proliferation in developing cerebellar granule neuron precursors.

Authors:  Anna Marie Kenney; Michael D Cole; David H Rowitch
Journal:  Development       Date:  2003-01       Impact factor: 6.868

Review 8.  Medulloblastoma stem cells.

Authors:  Xing Fan; Charles G Eberhart
Journal:  J Clin Oncol       Date:  2008-06-10       Impact factor: 44.544

9.  Math1 controls cerebellar granule cell differentiation by regulating multiple components of the Notch signaling pathway.

Authors:  Roi Gazit; Valery Krizhanovsky; Nissim Ben-Arie
Journal:  Development       Date:  2004-02       Impact factor: 6.868

10.  Analysis of cerebellar development in math1 null embryos and chimeras.

Authors:  Patricia Jensen; Richard Smeyne; Dan Goldowitz
Journal:  J Neurosci       Date:  2004-03-03       Impact factor: 6.167
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  12 in total

1.  Hypermethylated in cancer 1 (HIC1) recruits polycomb repressive complex 2 (PRC2) to a subset of its target genes through interaction with human polycomb-like (hPCL) proteins.

Authors:  Gaylor Boulay; Marion Dubuissez; Capucine Van Rechem; Antoine Forget; Kristian Helin; Olivier Ayrault; Dominique Leprince
Journal:  J Biol Chem       Date:  2012-02-07       Impact factor: 5.157

2.  The receptor tyrosine kinase EphA2 is a direct target gene of hypermethylated in cancer 1 (HIC1).

Authors:  Bénédicte Foveau; Gaylor Boulay; Sébastien Pinte; Capucine Van Rechem; Brian R Rood; Dominique Leprince
Journal:  J Biol Chem       Date:  2011-12-19       Impact factor: 5.157

3.  ATOH1 Promotes Leptomeningeal Dissemination and Metastasis of Sonic Hedgehog Subgroup Medulloblastomas.

Authors:  Katie B Grausam; Samuel D R Dooyema; Laure Bihannic; Hasitha Premathilake; A Sorana Morrissy; Antoine Forget; Amanda M Schaefer; Justin H Gundelach; Slobodan Macura; Diane M Maher; Xin Wang; Alex H Heglin; Xijin Ge; Erliang Zeng; Stephanie Puget; Indra Chandrasekar; Kameswaran Surendran; Richard J Bram; Ulrich Schüller; Michael D Talyor; Olivier Ayrault; Haotian Zhao
Journal:  Cancer Res       Date:  2017-05-10       Impact factor: 12.701

Review 4.  The role of Atonal transcription factors in the development of mechanosensitive cells.

Authors:  Andrew P Jarman; Andrew K Groves
Journal:  Semin Cell Dev Biol       Date:  2013-03-30       Impact factor: 7.727

5.  The Role of Atonal Factors in Mechanosensory Cell Specification and Function.

Authors:  Tiantian Cai; Andrew K Groves
Journal:  Mol Neurobiol       Date:  2014-10-23       Impact factor: 5.590

Review 6.  Cerebellum development and medulloblastoma.

Authors:  Martine F Roussel; Mary E Hatten
Journal:  Curr Top Dev Biol       Date:  2011       Impact factor: 4.897

7.  Prognostic relevance of high atonal homolog-1 expression in Merkel cell carcinoma.

Authors:  T Gambichler; S Mohtezebsade; U Wieland; S Silling; A-K Höh; M Dreißigacker; J Schaller; H-J Schulze; F Oellig; A Kreuter; E Stockfleth; M Stücker; F G Bechara; J C Becker
Journal:  J Cancer Res Clin Oncol       Date:  2016-09-13       Impact factor: 4.553

Review 8.  Deciphering HIC1 control pathways to reveal new avenues in cancer therapeutics.

Authors:  Brian R Rood; Dominique Leprince
Journal:  Expert Opin Ther Targets       Date:  2013-04-09       Impact factor: 6.902

Review 9.  The genetics of hair cell development and regeneration.

Authors:  Andrew K Groves; Kaidi D Zhang; Donna M Fekete
Journal:  Annu Rev Neurosci       Date:  2013-05-29       Impact factor: 12.449

10.  Novel gene expression model for outcome prediction in paediatric medulloblastoma.

Authors:  Magdalena Zakrzewska; Sylwia M Grešner; Krzysztof Zakrzewski; Beata Zalewska-Szewczyk; Pawel P Liberski
Journal:  J Mol Neurosci       Date:  2013-05-07       Impact factor: 3.444
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